@inproceedings{60bcec5c02ec432b9d265e0c933b93b8,
title = "Label-free rapid detection of pathogens with antimicrobial peptide assisted impedance spectrometry",
abstract = "An urgent need exist for developing handheld devices for rapid, sensitive, and specific detection method for pathogens. Here we demonstrate a rapid detection method for Gram-positive and Gram-negative bacteria using an impedance sensor array functionalized with antimicrobial peptides (AMPs). This impedance sensor screens pathogens in real-time and has comparable sensitivity with current detection methods like polymerase chain reaction (PCR) and immunoassay. Functionalized electrodes in array selectively bind to the corresponding bacteria strains, resulting in variations in the impedance modulus. Impedance variation is used to detect incubated bacterial cell concentration with a resolution of 1 cell \textbackslash{}iL'1. The dynamic range of detection for both Gram-positive and Gram-negative bacteria is found to be 103-106 cm mL{"}1. Micropattemed electrodes modified with AMPs in an impedimetric array offer an excellent platform for rapid and selective detection of pathogens in contaminated water and food products.",
author = "Keren Jiang and Hashem Etayash and Sarfuddin Azmi and Garima Thakur and Selvaraj Naicker and Kamaljit Kaur and Thundat Thomas",
note = "Publisher Copyright: {\textcopyright} 2015 Materials Research Society.; 2015 MRS Spring Meeting ; Conference date: 06-04-2015 Through 10-04-2015",
year = "2015",
doi = "10.1557/opl.2015.619",
language = "English",
series = "Materials Research Society Symposium Proceedings",
publisher = "Materials Research Society",
pages = "13--18",
editor = "Hendrik Heinz and Perry, \{Carole C.\} and Candan Tamerler and Yuhei Hayamizu",
booktitle = "Foundations of Bio/Nano Interfaces - Synthesis, Modeling, Design Principles and Applications",
}