Juvenile Periodontitis as a Model for Neutrophil Function: Reduced Binding of the Complement Chemotactic Fragment, C5a

T. E. Van Dyke; M. J. Levine; L. A. Tabak; R. J. Genco

doi:10.1177/00220345830620080301

Juvenile Periodontitis as a Model for Neutrophil Function: Reduced Binding of the Complement Chemotactic Fragment, C5a

T. E. Van Dyke
, M. J. Levine
, L. A. Tabak
, R. J. Genco

Department of Oral Biology

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The binding of the chemotactic complement fragment, C5a, to peripheral blood neutrophils of Localized Juvenile Periodontitis (LJP) patients and normal controls was quantitated using iodinated human C5a and a rapid centrifugation assay. There was a significant reduction in the number of binding sites per cell on neutrophils from the patient group, whereas the binding affinity remained the same as control values.

Original language	English
Pages (from-to)	870-872
Number of pages	3
Journal	Journal of Dental Research
Volume	62
Issue number	8
DOIs	https://doi.org/10.1177/00220345830620080301
State	Published - Aug 1983

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title = "Juvenile Periodontitis as a Model for Neutrophil Function: Reduced Binding of the Complement Chemotactic Fragment, C5a",

abstract = "The binding of the chemotactic complement fragment, C5a, to peripheral blood neutrophils of Localized Juvenile Periodontitis (LJP) patients and normal controls was quantitated using iodinated human C5a and a rapid centrifugation assay. There was a significant reduction in the number of binding sites per cell on neutrophils from the patient group, whereas the binding affinity remained the same as control values.",

author = "\{Van Dyke\}, \{T. E.\} and Levine, \{M. J.\} and Tabak, \{L. A.\} and Genco, \{R. J.\}",

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T2 - Reduced Binding of the Complement Chemotactic Fragment, C5a

AU - Van Dyke, T. E.

AU - Levine, M. J.

AU - Tabak, L. A.

AU - Genco, R. J.

PY - 1983/8

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N2 - The binding of the chemotactic complement fragment, C5a, to peripheral blood neutrophils of Localized Juvenile Periodontitis (LJP) patients and normal controls was quantitated using iodinated human C5a and a rapid centrifugation assay. There was a significant reduction in the number of binding sites per cell on neutrophils from the patient group, whereas the binding affinity remained the same as control values.

AB - The binding of the chemotactic complement fragment, C5a, to peripheral blood neutrophils of Localized Juvenile Periodontitis (LJP) patients and normal controls was quantitated using iodinated human C5a and a rapid centrifugation assay. There was a significant reduction in the number of binding sites per cell on neutrophils from the patient group, whereas the binding affinity remained the same as control values.

UR - https://www.scopus.com/pages/publications/0020805455

U2 - 10.1177/00220345830620080301

DO - 10.1177/00220345830620080301

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AN - SCOPUS:0020805455

SN - 0022-0345

VL - 62

SP - 870

EP - 872

JO - Journal of Dental Research

JF - Journal of Dental Research

IS - 8

ER -

Juvenile Periodontitis as a Model for Neutrophil Function: Reduced Binding of the Complement Chemotactic Fragment, C5a

Abstract

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