Is there a unique conformation of cholinergic ligands responsible for muscarinic activity?

Eli Shefter; David J. Triggle

doi:10.1038/2271354a0

Is there a unique conformation of cholinergic ligands responsible for muscarinic activity?

Eli Shefter
, David J. Triggle

School of Pharmacy and Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

CHOTHIA¹ has proposed a structure activity relationship for the muscarinic response of acetylcholine. In deriving the model responsible for optimum activity, reports on the pharmacological testing of a number of conformationally constrained acetylcholine analogues were neglected.

Original language	English
Pages (from-to)	1354-1355
Number of pages	2
Journal	Nature
Volume	227
Issue number	5265
DOIs	https://doi.org/10.1038/2271354a0
State	Published - 1970

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10.1038/2271354a0

Cite this

@article{8240460cdbdb42ae9e1f280f60da231d,

title = "Is there a unique conformation of cholinergic ligands responsible for muscarinic activity?",

abstract = "CHOTHIA1 has proposed a structure activity relationship for the muscarinic response of acetylcholine. In deriving the model responsible for optimum activity, reports on the pharmacological testing of a number of conformationally constrained acetylcholine analogues were neglected.",

author = "Eli Shefter and Triggle, \{David J.\}",

year = "1970",

doi = "10.1038/2271354a0",

language = "English",

volume = "227",

pages = "1354--1355",

journal = "Nature",

issn = "0028-0836",