Ion channels as pharmacologic receptors: The chirality of drug interactions

David J. Triggle

doi:10.1002/(SICI)1520-636X(1996)8:1<35::AID-CHIR8>3.0.CO;2-F

Ion channels as pharmacologic receptors: The chirality of drug interactions

David J. Triggle

School of Pharmacy and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Ion channels are pharmacologic receptors and as such exhibit stereoselective interactions with drugs. Ion channels are conformationally mobile transmembrane proteins existing in a number of open and closed states. Drug interactions with these different states may differ quantitatively and qualitatively. Stereoselectivity may not be a constant factor and may change according to channel state as determined by stimulus mode or experimental conditions. Selected examples are cited for Na⁺ and Ca²⁺ channels.

Original language	English
Pages (from-to)	35-38
Number of pages	4
Journal	Chirality
Volume	8
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1520-636X(1996)8:1<35::AID-CHIR8>3.0.CO;2-F
State	Published - 1996

Keywords

1,4-dihydropyridines
Ca channels
ion channels
local anesthetics
Na channels
receptors
state-dependent interactions
stereoselectivity

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10.1002/(SICI)1520-636X(1996)8:1<35::AID-CHIR8>3.0.CO;2-F

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AB - Ion channels are pharmacologic receptors and as such exhibit stereoselective interactions with drugs. Ion channels are conformationally mobile transmembrane proteins existing in a number of open and closed states. Drug interactions with these different states may differ quantitatively and qualitatively. Stereoselectivity may not be a constant factor and may change according to channel state as determined by stimulus mode or experimental conditions. Selected examples are cited for Na+ and Ca2+ channels.

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KW - receptors

KW - state-dependent interactions

KW - stereoselectivity

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Ion channels as pharmacologic receptors: The chirality of drug interactions

Abstract

Keywords

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