Intracranial self-stimulation as a technique to study the reward properties of drugs of abuse

Michael A. Bozarth; Gary J. Gerber; Roy A. Wise

doi:10.1016/S0091-3057(80)80037-2

Intracranial self-stimulation as a technique to study the reward properties of drugs of abuse

Michael A. Bozarth
, Gary J. Gerber
, Roy A. Wise

Psychology

Concordia University

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Rats allowed concurrent access to intravenous heroin and intracranial self-stimulation (ICSS) showed facilitation of ICSS while maintaining stable self-administration of heroin. The facilitatory action of heroin on ICSS was indexed by an increase in response rates and a lowering of intensity thresholds. Both measures showed dose-dependent changes, but only threshold tracking allowed a reliable determination of the time-dependent effect of self-administered heroin on ICSS.

Original language	English
Pages (from-to)	245-247
Number of pages	3
Journal	Pharmacology Biochemistry and Behavior
Volume	13
DOIs	https://doi.org/10.1016/S0091-3057(80)80037-2
State	Published - 1980

Keywords

Effect of heroin on intracranial self-stimulation
Heroin self-administration
Intracranial self-stimulation
Threshold tracking

Access to Document

10.1016/S0091-3057(80)80037-2

Cite this

@article{a94cc9b3d1014004af82875de3d36aa8,

title = "Intracranial self-stimulation as a technique to study the reward properties of drugs of abuse",

abstract = "Rats allowed concurrent access to intravenous heroin and intracranial self-stimulation (ICSS) showed facilitation of ICSS while maintaining stable self-administration of heroin. The facilitatory action of heroin on ICSS was indexed by an increase in response rates and a lowering of intensity thresholds. Both measures showed dose-dependent changes, but only threshold tracking allowed a reliable determination of the time-dependent effect of self-administered heroin on ICSS.",

keywords = "Effect of heroin on intracranial self-stimulation, Heroin self-administration, Intracranial self-stimulation, Threshold tracking",

author = "Bozarth, \{Michael A.\} and Gerber, \{Gary J.\} and Wise, \{Roy A.\}",

year = "1980",

doi = "10.1016/S0091-3057(80)80037-2",

language = "English",

volume = "13",

pages = "245--247",

journal = "Pharmacology Biochemistry and Behavior",

issn = "0091-3057",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Intracranial self-stimulation as a technique to study the reward properties of drugs of abuse

AU - Bozarth, Michael A.

AU - Gerber, Gary J.

AU - Wise, Roy A.

PY - 1980

Y1 - 1980

N2 - Rats allowed concurrent access to intravenous heroin and intracranial self-stimulation (ICSS) showed facilitation of ICSS while maintaining stable self-administration of heroin. The facilitatory action of heroin on ICSS was indexed by an increase in response rates and a lowering of intensity thresholds. Both measures showed dose-dependent changes, but only threshold tracking allowed a reliable determination of the time-dependent effect of self-administered heroin on ICSS.

AB - Rats allowed concurrent access to intravenous heroin and intracranial self-stimulation (ICSS) showed facilitation of ICSS while maintaining stable self-administration of heroin. The facilitatory action of heroin on ICSS was indexed by an increase in response rates and a lowering of intensity thresholds. Both measures showed dose-dependent changes, but only threshold tracking allowed a reliable determination of the time-dependent effect of self-administered heroin on ICSS.

KW - Effect of heroin on intracranial self-stimulation

KW - Heroin self-administration

KW - Intracranial self-stimulation

KW - Threshold tracking

UR - https://www.scopus.com/pages/publications/0019491639

U2 - 10.1016/S0091-3057(80)80037-2

DO - 10.1016/S0091-3057(80)80037-2

M3 - Article

C2 - 7195575

AN - SCOPUS:0019491639

SN - 0091-3057

VL - 13

SP - 245

EP - 247

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

ER -

Intracranial self-stimulation as a technique to study the reward properties of drugs of abuse

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this