Intoxication Caused by Interaction of Chloramphenicol and Phenytoin

James Q. Rose; Hee K. Choi; Jerome J. Schentag; William R. Kinkel; William J. Jusko

doi:10.1001/jama.1977.03270510052024

Intoxication Caused by Interaction of Chloramphenicol and Phenytoin

James Q. Rose
, Hee K. Choi
, Jerome J. Schentag
, William R. Kinkel
, William J. Jusko

SUNY Buffalo
Women and Children's Hospital of Buffalo

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A patient with a brain tumor and seizures who was receiving maintenance doses of phenytoin was given chloramphenicol on three occasions. Her neurological status was both complicated and obscured by the reoccurrence of phenytoin intoxication. Retrospective drug analysis showed a marked elevation of serum concentrations of phenytoin during each course of chloramphenicol.

Original language	English
Pages (from-to)	2630-2631
Number of pages	2
Journal	JAMA: The Journal of the American Medical Association
Volume	237
Issue number	24
DOIs	https://doi.org/10.1001/jama.1977.03270510052024
State	Published - Jun 13 1977

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10.1001/jama.1977.03270510052024

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title = "Intoxication Caused by Interaction of Chloramphenicol and Phenytoin",

abstract = "A patient with a brain tumor and seizures who was receiving maintenance doses of phenytoin was given chloramphenicol on three occasions. Her neurological status was both complicated and obscured by the reoccurrence of phenytoin intoxication. Retrospective drug analysis showed a marked elevation of serum concentrations of phenytoin during each course of chloramphenicol.",

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AU - Rose, James Q.

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AU - Jusko, William J.

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AB - A patient with a brain tumor and seizures who was receiving maintenance doses of phenytoin was given chloramphenicol on three occasions. Her neurological status was both complicated and obscured by the reoccurrence of phenytoin intoxication. Retrospective drug analysis showed a marked elevation of serum concentrations of phenytoin during each course of chloramphenicol.

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Intoxication Caused by Interaction of Chloramphenicol and Phenytoin

Abstract

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