Into the Future: New Investigations on Autoimmune Reactions Against Cardiac Structures

Penny McCreath; Adrian Baranchuk; Animesh Sinha; Meena Fatah; Diptendu Chatterjee; Robert Hamilton

doi:10.1007/978-3-031-41169-4_18

Into the Future: New Investigations on Autoimmune Reactions Against Cardiac Structures

Penny McCreath
, Adrian Baranchuk
, Animesh Sinha
, Meena Fatah
, Diptendu Chatterjee
, Robert Hamilton

Department of Dermatology

Queen's University Kingston
University of Toronto

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The incidence of Lyme carditis is expected to increase due to human migration, reforestation, and climate mediated improvement. Autoantibody biomarkers of Lyme carditis can: (a) stratify affected individuals based on their risk of a sustained immune response and cardiac involvement, thereby facilitating proactive treatment regimens; and (b) be targeted in future precision medicine therapies, improving the quality of care for patients with Lyme carditis. A unique autoantibody profile of abnormally expressed cardiac proteins is likely present in Lyme disease. Discovery of biomarkers of cardiac involvement in Lyme disease will help to elucidate the sequelae leading to sustained humoral autoimmunity following initial infection with Lyme disease.

Original language	English
Title of host publication	Lyme Carditis
Subtitle of host publication	From A to Z
Publisher	Springer International Publishing
Pages	161-164
Number of pages	4
ISBN (Electronic)	9783031411694
ISBN (Print)	9783031411687
DOIs	https://doi.org/10.1007/978-3-031-41169-4_18
State	Published - Jan 1 2023

Keywords

Autoantibody
Autoantibody biomarkers
Autoimmunity
Biomarkers
Lyme carditis
Lyme disease

Access to Document

10.1007/978-3-031-41169-4_18

Cite this

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Into the Future: New Investigations on Autoimmune Reactions Against Cardiac Structures

Abstract

Keywords

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