Abstract
Antiangiogenic activity-guided fractionation and isolation carried out on the methanol extract of Adonis amurensis led to the identification of three compounds, namely cymarin, cymarol, and cymarilic acid. Amongst the three compounds, cymarilic acid was isolated from this plant for the first time. This compound showed no significant cytotoxicity against tumor cell lines but was found to be strongly inhibitory toward tube formation induced by human umbilical venous endothelial (HUVE) cells. Cymarin and cymarol exhibited potent cytotoxicity against a human solid tumor cell line A549 (human lung carcinoma), while being inactive on murine leukemic cells (L1210).
| Original language | English |
|---|---|
| Pages (from-to) | 568-570 |
| Number of pages | 3 |
| Journal | Phytotherapy Research |
| Volume | 17 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2003 |
Keywords
- Adonis amurensis
- Antiangiogenic
- Cymarilic acid
- Cytotoxic
Fingerprint
Dive into the research topics of 'Inhibitory effect of Adonis amurensis components on tube-like formation of human umbilical venous cells'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver