Inhibition of IL-6 and IL-8 production in human fibroblast cell lines by 1,25 (OH)2 vitamin D3 and two of its analogs with lower calcemic activity

M. D. Srviastava; H. DeLuca; J. L. Ambrus

Inhibition of IL-6 and IL-8 production in human fibroblast cell lines by 1,25 (OH)₂ vitamin D₃ and two of its analogs with lower calcemic activity

M. D. Srviastava
, H. DeLuca
, J. L. Ambrus

Medicine

Women and Children's Hospital of Buffalo

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

In human fibroblast cultures TPA increased IL-6 and IL-8 production. This was reduced by vitamin D₃ metabolites and analogs. The two analogs employed: 1,25 (OH)₂-22 (E)-dehydro-24-monohomo vitamin D₃ (Compound A) and 1,25 (OH)₂ -22 (E)-dehydro-24 dihomo-vitamin D₃ (Compound B) may be useful in the therapy of pathologic proliferative disorders including psoriasis, particularly since they are less toxic and have less effect on calcium metabolism than vitamin D₃.

Original language	English
Pages (from-to)	145-150
Number of pages	6
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	83
Issue number	2
State	Published - 1994

Cite this

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title = "Inhibition of IL-6 and IL-8 production in human fibroblast cell lines by 1,25 (OH)2 vitamin D3 and two of its analogs with lower calcemic activity",

abstract = "In human fibroblast cultures TPA increased IL-6 and IL-8 production. This was reduced by vitamin D3 metabolites and analogs. The two analogs employed: 1,25 (OH)2-22 (E)-dehydro-24-monohomo vitamin D3 (Compound A) and 1,25 (OH)2 -22 (E)-dehydro-24 dihomo-vitamin D3 (Compound B) may be useful in the therapy of pathologic proliferative disorders including psoriasis, particularly since they are less toxic and have less effect on calcium metabolism than vitamin D3.",

author = "Srviastava, \{M. D.\} and H. DeLuca and Ambrus, \{J. L.\}",

year = "1994",

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journal = "Research Communications in Chemical Pathology and Pharmacology",

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T1 - Inhibition of IL-6 and IL-8 production in human fibroblast cell lines by 1,25 (OH)2 vitamin D3 and two of its analogs with lower calcemic activity

AU - Srviastava, M. D.

AU - DeLuca, H.

AU - Ambrus, J. L.

PY - 1994

Y1 - 1994

N2 - In human fibroblast cultures TPA increased IL-6 and IL-8 production. This was reduced by vitamin D3 metabolites and analogs. The two analogs employed: 1,25 (OH)2-22 (E)-dehydro-24-monohomo vitamin D3 (Compound A) and 1,25 (OH)2 -22 (E)-dehydro-24 dihomo-vitamin D3 (Compound B) may be useful in the therapy of pathologic proliferative disorders including psoriasis, particularly since they are less toxic and have less effect on calcium metabolism than vitamin D3.

AB - In human fibroblast cultures TPA increased IL-6 and IL-8 production. This was reduced by vitamin D3 metabolites and analogs. The two analogs employed: 1,25 (OH)2-22 (E)-dehydro-24-monohomo vitamin D3 (Compound A) and 1,25 (OH)2 -22 (E)-dehydro-24 dihomo-vitamin D3 (Compound B) may be useful in the therapy of pathologic proliferative disorders including psoriasis, particularly since they are less toxic and have less effect on calcium metabolism than vitamin D3.

UR - https://www.scopus.com/pages/publications/0028174375

M3 - Article

C2 - 8202627

AN - SCOPUS:0028174375

SN - 0034-5164

VL - 83

SP - 145

EP - 150

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

IS - 2

ER -

Inhibition of IL-6 and IL-8 production in human fibroblast cell lines by 1,25 (OH)₂ vitamin D₃ and two of its analogs with lower calcemic activity

Abstract

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