Inhibition of Cyclic Nucleotide Phosphodiesterases to Regulate Memory

Han Ting Zhang; Ying Xu; James O'Donnell

doi:10.1002/9781118836507.ch07

Inhibition of Cyclic Nucleotide Phosphodiesterases to Regulate Memory

Han Ting Zhang
, Ying Xu
, James O'Donnell

Pharmaceutical Sciences

West Virginia University
SUNY Buffalo

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

The 11 cyclic nucleotide phosphodiesterase (PDE) families are differentially distributed in the brain, suggesting that they contribute in unique ways to central nervous system functions. Given that PDE1, PDE2, PDE4, PDE7, PDE9, and PDE10 are enriched in the hippocampus, amygdala, and neostriatum, they may contribute significantly in the mediation of memory. In this chapter, the roles of the different PDE families and their isoforms in mediating memory and the mechanisms involved are reviewed.

Original language	English
Title of host publication	Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System
Subtitle of host publication	From Biology to Drug Discovery
Publisher	Wiley-Blackwell
Pages	171-210
Number of pages	40
ISBN (Electronic)	9781118836507
ISBN (Print)	9780470566688
DOIs	https://doi.org/10.1002/9781118836507.ch07
State	Published - Apr 28 2014

Keywords

Cyclic AMP (cAMP)
Cyclic GMP (cGMP)
Memory
Phosphodiesterase (PDE)

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10.1002/9781118836507.ch07

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abstract = "The 11 cyclic nucleotide phosphodiesterase (PDE) families are differentially distributed in the brain, suggesting that they contribute in unique ways to central nervous system functions. Given that PDE1, PDE2, PDE4, PDE7, PDE9, and PDE10 are enriched in the hippocampus, amygdala, and neostriatum, they may contribute significantly in the mediation of memory. In this chapter, the roles of the different PDE families and their isoforms in mediating memory and the mechanisms involved are reviewed.",

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KW - Cyclic AMP (cAMP)

KW - Cyclic GMP (cGMP)

KW - Memory

KW - Phosphodiesterase (PDE)

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BT - Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System

PB - Wiley-Blackwell

ER -

Inhibition of Cyclic Nucleotide Phosphodiesterases to Regulate Memory

Abstract

Keywords

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