Influence of age, sex and diurnal variability on imipramine receptor binding and serotonin uptake in platelets of normal subjects

Uriel Halbreich; Nathan Rojansky; Karl J. Zander; Amiram Barkai

doi:10.1016/0022-3956(91)90012-Y

Influence of age, sex and diurnal variability on imipramine receptor binding and serotonin uptake in platelets of normal subjects

Uriel Halbreich
, Nathan Rojansky
, Karl J. Zander
, Amiram Barkai

Department of Psychiatry

SUNY Buffalo
Albert Einstein College of Medicine
Columbia University

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Imipramine (IMI) binding and serotonin (5-HT) uptake were determined in platelets of 98 healthy volunteers; and their association with age, sex and circadian rhythm were evaluated. A large interindividual variability was found for both IMI and 5-HT parameters. There was a negative correlation of IMI affinity constant (Kd) and binding (B_max) with age, but no such correlation of 5-HT affinity constant (Km) or uptake (V_max). Significant age-related diurnal variability was found for 5-HT Km in the whole group as well as for IMI Kd in males, but not in females. There was no significant correlation between 5-HT V_max and IMI B_max. Our results underscore a cautious approach to the interpretation of platelet serotonergic studies. In light of the multiple variables influencing the results, the usefulness of IMI or 5-HT as clinical markers should be re-evaluated.

Original language	English
Pages (from-to)	7-18
Number of pages	12
Journal	Journal of Psychiatric Research
Volume	25
Issue number	1-2
DOIs	https://doi.org/10.1016/0022-3956(91)90012-Y
State	Published - 1991

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title = "Influence of age, sex and diurnal variability on imipramine receptor binding and serotonin uptake in platelets of normal subjects",

abstract = "Imipramine (IMI) binding and serotonin (5-HT) uptake were determined in platelets of 98 healthy volunteers; and their association with age, sex and circadian rhythm were evaluated. A large interindividual variability was found for both IMI and 5-HT parameters. There was a negative correlation of IMI affinity constant (Kd) and binding (Bmax) with age, but no such correlation of 5-HT affinity constant (Km) or uptake (Vmax). Significant age-related diurnal variability was found for 5-HT Km in the whole group as well as for IMI Kd in males, but not in females. There was no significant correlation between 5-HT Vmax and IMI Bmax. Our results underscore a cautious approach to the interpretation of platelet serotonergic studies. In light of the multiple variables influencing the results, the usefulness of IMI or 5-HT as clinical markers should be re-evaluated.",

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T1 - Influence of age, sex and diurnal variability on imipramine receptor binding and serotonin uptake in platelets of normal subjects

AU - Halbreich, Uriel

AU - Rojansky, Nathan

AU - Zander, Karl J.

AU - Barkai, Amiram

PY - 1991

Y1 - 1991

N2 - Imipramine (IMI) binding and serotonin (5-HT) uptake were determined in platelets of 98 healthy volunteers; and their association with age, sex and circadian rhythm were evaluated. A large interindividual variability was found for both IMI and 5-HT parameters. There was a negative correlation of IMI affinity constant (Kd) and binding (Bmax) with age, but no such correlation of 5-HT affinity constant (Km) or uptake (Vmax). Significant age-related diurnal variability was found for 5-HT Km in the whole group as well as for IMI Kd in males, but not in females. There was no significant correlation between 5-HT Vmax and IMI Bmax. Our results underscore a cautious approach to the interpretation of platelet serotonergic studies. In light of the multiple variables influencing the results, the usefulness of IMI or 5-HT as clinical markers should be re-evaluated.

AB - Imipramine (IMI) binding and serotonin (5-HT) uptake were determined in platelets of 98 healthy volunteers; and their association with age, sex and circadian rhythm were evaluated. A large interindividual variability was found for both IMI and 5-HT parameters. There was a negative correlation of IMI affinity constant (Kd) and binding (Bmax) with age, but no such correlation of 5-HT affinity constant (Km) or uptake (Vmax). Significant age-related diurnal variability was found for 5-HT Km in the whole group as well as for IMI Kd in males, but not in females. There was no significant correlation between 5-HT Vmax and IMI Bmax. Our results underscore a cautious approach to the interpretation of platelet serotonergic studies. In light of the multiple variables influencing the results, the usefulness of IMI or 5-HT as clinical markers should be re-evaluated.

UR - https://www.scopus.com/pages/publications/0025971106

U2 - 10.1016/0022-3956(91)90012-Y

DO - 10.1016/0022-3956(91)90012-Y

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AN - SCOPUS:0025971106

SN - 0022-3956

VL - 25

SP - 7

EP - 18

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

IS - 1-2

ER -

Influence of age, sex and diurnal variability on imipramine receptor binding and serotonin uptake in platelets of normal subjects

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