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Indwelling Urinary Catheter Model of Proteus mirabilis Infection

  • University of Michigan, Ann Arbor

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

10 Scopus citations

Abstract

Uncomplicated urinary tract infections, especially those caused by Escherichia coli, have historically been widely studied. However, complicated urinary tract infections are presenting ever increasing healthcare challenges, particularly with Proteus mirabilis. P. mirabilis is often found on indwelling urinary catheters causing monomicrobial and polymicrobial catheter-associated urinary tract infection (CAUTI). Widespread antibiotic resistance, combined with the ability of P. mirabilis to form urinary calculi during infection, warrants further investigation of this pathogen and its host interaction in an infection model that more closely mimics the presence of an indwelling urinary catheter. Here, we describe the methods necessary to establish a murine model of P. mirabilis CAUTI.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages187-200
Number of pages14
DOIs
StatePublished - 2019

Publication series

NameMethods in Molecular Biology
Volume2021
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Catheter-associated urinary tract infection
  • Indwelling catheter
  • Mouse infection model
  • Proteus mirabilis

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