Increased prostaglandin E2 and cAMP phosphodiesterase levels in Kaposi's sarcoma - A virus against host defense mechanism

J. L. Ambrus; H. L. Stoll; E. A. Klein; C. P. Karakousis; S. Stadler

Increased prostaglandin E₂ and cAMP phosphodiesterase levels in Kaposi's sarcoma - A virus against host defense mechanism

J. L. Ambrus
, H. L. Stoll
, E. A. Klein
, C. P. Karakousis
, S. Stadler

Medicine

Women and Children's Hospital of Buffalo

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

In Kaposi's sarcoma tissue, prostaglandin E₂ (PgE₂) levels and cAMP phosphodiesterase levels were found to be higher than in surrounding normal tissue. We have shown earlier that PgE₂ suppresses interferon (IFN) alpha production. High levels of cAMP phosphodiesterases result in low cAMP levels. Thus, this phenomenon may be involved in altered immunologic resistance, growth and differentiation.

Original language	English
Pages (from-to)	249-252
Number of pages	4
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	78
Issue number	2
State	Published - 1992

Cite this

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title = "Increased prostaglandin E2 and cAMP phosphodiesterase levels in Kaposi's sarcoma - A virus against host defense mechanism",

abstract = "In Kaposi's sarcoma tissue, prostaglandin E2 (PgE2) levels and cAMP phosphodiesterase levels were found to be higher than in surrounding normal tissue. We have shown earlier that PgE2 suppresses interferon (IFN) alpha production. High levels of cAMP phosphodiesterases result in low cAMP levels. Thus, this phenomenon may be involved in altered immunologic resistance, growth and differentiation.",

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T1 - Increased prostaglandin E2 and cAMP phosphodiesterase levels in Kaposi's sarcoma - A virus against host defense mechanism

AU - Ambrus, J. L.

AU - Stoll, H. L.

AU - Klein, E. A.

AU - Karakousis, C. P.

AU - Stadler, S.

PY - 1992

Y1 - 1992

N2 - In Kaposi's sarcoma tissue, prostaglandin E2 (PgE2) levels and cAMP phosphodiesterase levels were found to be higher than in surrounding normal tissue. We have shown earlier that PgE2 suppresses interferon (IFN) alpha production. High levels of cAMP phosphodiesterases result in low cAMP levels. Thus, this phenomenon may be involved in altered immunologic resistance, growth and differentiation.

AB - In Kaposi's sarcoma tissue, prostaglandin E2 (PgE2) levels and cAMP phosphodiesterase levels were found to be higher than in surrounding normal tissue. We have shown earlier that PgE2 suppresses interferon (IFN) alpha production. High levels of cAMP phosphodiesterases result in low cAMP levels. Thus, this phenomenon may be involved in altered immunologic resistance, growth and differentiation.

UR - https://www.scopus.com/pages/publications/0026614672

M3 - Article

C2 - 1335594

AN - SCOPUS:0026614672

SN - 0034-5164

VL - 78

SP - 249

EP - 252

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

IS - 2

ER -

Increased prostaglandin E₂ and cAMP phosphodiesterase levels in Kaposi's sarcoma - A virus against host defense mechanism

Abstract

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