Increased Content Of Glucocorticoid Receptors In Mouse Muscular Dystrophy

An analysis of the glucocorticoid receptor population of skeletal muscle and liver from dystrophic and control mice was performed. These data demonstrate that the cytosol of muscles from dystrophic animals contain a significantly higher concentration of glucocorticoid receptors (approximately 100%) relative to the cytosols of muscles from control mice. No differences in the glucocorticoid receptor population was noted in the livers removed from these animals. These data are consistent with previous observations on the chicken dystrophic model, and may suggest a general phenomenon associated with dystrophy regardless of species or type.