In vitro and animal models of human immunodeficiency virus infection of the central nervous system

Each of the model systems outlined in this review has applicability to HIV research. Obviously, some are more useful than others, and refinement of the presently available systems is occurring continually. Further development of these models will enable the research community to broaden our knowledge of the pathogenesis of AIDS encephalopathy. However, effective treatment of this major complication of HIV infection remains elusive. The further development of nonprimate animal systems to assess the efficacy of potential therapies for AIDS encephalopathy is an important goal.