In situ detection of calcium ions with chemically modified microcantilevers

Hai Feng Ji; Thomas Thundat

doi:10.1016/S0956-5663(01)00270-6

In situ detection of calcium ions with chemically modified microcantilevers

Hai Feng Ji
, Thomas Thundat

Department of Chemical and Biological Engineering

Oak Ridge National Laboratory

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

We report a novel technique of micromechanical detection of trace amounts of calcium ions by using microcantilevers modified with ion-selective self-assembled monolayers (SAMs). The SAM-modified microcantilevers undergo bending due to selective adsorption of calcium ions. Experiments conducted under flow conditions show that the modified cantilevers respond sensitively to calcium ions (Ca²⁺); a Ca²⁺ concentration of 10^-9 M can be detected with this technique. Other cations, such as Na⁺ and K⁺, do not have any effect on the deflection of these cantilevers. We demonstrate two different kinds of SAMs having selectivity for calcium ions.

Original language	English
Pages (from-to)	337-343
Number of pages	7
Journal	Biosensors and Bioelectronics
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/S0956-5663(01)00270-6
State	Published - 2002

Keywords

Calcium ion detection
Microcantilevers
Selective coatings
Self assembled monolayers

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10.1016/S0956-5663(01)00270-6

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abstract = "We report a novel technique of micromechanical detection of trace amounts of calcium ions by using microcantilevers modified with ion-selective self-assembled monolayers (SAMs). The SAM-modified microcantilevers undergo bending due to selective adsorption of calcium ions. Experiments conducted under flow conditions show that the modified cantilevers respond sensitively to calcium ions (Ca2+); a Ca2+ concentration of 10-9 M can be detected with this technique. Other cations, such as Na+ and K+, do not have any effect on the deflection of these cantilevers. We demonstrate two different kinds of SAMs having selectivity for calcium ions.",

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AU - Ji, Hai Feng

AU - Thundat, Thomas

PY - 2002

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N2 - We report a novel technique of micromechanical detection of trace amounts of calcium ions by using microcantilevers modified with ion-selective self-assembled monolayers (SAMs). The SAM-modified microcantilevers undergo bending due to selective adsorption of calcium ions. Experiments conducted under flow conditions show that the modified cantilevers respond sensitively to calcium ions (Ca2+); a Ca2+ concentration of 10-9 M can be detected with this technique. Other cations, such as Na+ and K+, do not have any effect on the deflection of these cantilevers. We demonstrate two different kinds of SAMs having selectivity for calcium ions.

AB - We report a novel technique of micromechanical detection of trace amounts of calcium ions by using microcantilevers modified with ion-selective self-assembled monolayers (SAMs). The SAM-modified microcantilevers undergo bending due to selective adsorption of calcium ions. Experiments conducted under flow conditions show that the modified cantilevers respond sensitively to calcium ions (Ca2+); a Ca2+ concentration of 10-9 M can be detected with this technique. Other cations, such as Na+ and K+, do not have any effect on the deflection of these cantilevers. We demonstrate two different kinds of SAMs having selectivity for calcium ions.

KW - Calcium ion detection

KW - Microcantilevers

KW - Selective coatings

KW - Self assembled monolayers

UR - https://www.scopus.com/pages/publications/0036178311

U2 - 10.1016/S0956-5663(01)00270-6

DO - 10.1016/S0956-5663(01)00270-6

M3 - Article

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AN - SCOPUS:0036178311

SN - 0956-5663

VL - 17

SP - 337

EP - 343

JO - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

IS - 4

ER -

In situ detection of calcium ions with chemically modified microcantilevers

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Keywords

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