Implantable Tin Porphyrin-PEG Hydrogels with pH-Responsive Fluorescence

Haoyuan Huang; Saurabh Chauhan; Jumin Geng; Yiru Qin; David F. Watson; Jonathan F. Lovell

doi:10.1021/acs.biomac.6b01715

Implantable Tin Porphyrin-PEG Hydrogels with pH-Responsive Fluorescence

Haoyuan Huang
, Saurabh Chauhan
, Jumin Geng
, Yiru Qin
, David F. Watson
, Jonathan F. Lovell

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Tetracarboxy porphyrins can be polymerized with polyethylene glycol (PEG) diamines to generate hydrogels with intense, near-infrared, and transdermal fluorescence following subcutaneous implantation. Here, we show that the high density porphyrins of the preformed polymer can be chelated with tin via simple incubation. Tin porphyrin hydrogels exhibited increasing emission intensities, ratios, and lifetimes from pH 1 to 10. Tin porphyrin hydrogel emission was strongly reversible and pH responsiveness was observed in the physiological range between pH 6 and pH 8. pH-sensitive emission was detected via noninvasive transdermal fluorescence imaging in vivo following subcutaneous implantation in mice.

Original language	English
Pages (from-to)	562-567
Number of pages	6
Journal	Biomacromolecules
Volume	18
Issue number	2
DOIs	https://doi.org/10.1021/acs.biomac.6b01715
State	Published - Feb 13 2017

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title = "Implantable Tin Porphyrin-PEG Hydrogels with pH-Responsive Fluorescence",

abstract = "Tetracarboxy porphyrins can be polymerized with polyethylene glycol (PEG) diamines to generate hydrogels with intense, near-infrared, and transdermal fluorescence following subcutaneous implantation. Here, we show that the high density porphyrins of the preformed polymer can be chelated with tin via simple incubation. Tin porphyrin hydrogels exhibited increasing emission intensities, ratios, and lifetimes from pH 1 to 10. Tin porphyrin hydrogel emission was strongly reversible and pH responsiveness was observed in the physiological range between pH 6 and pH 8. pH-sensitive emission was detected via noninvasive transdermal fluorescence imaging in vivo following subcutaneous implantation in mice.",

author = "Haoyuan Huang and Saurabh Chauhan and Jumin Geng and Yiru Qin and Watson, \{David F.\} and Lovell, \{Jonathan F.\}",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

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AU - Huang, Haoyuan

AU - Chauhan, Saurabh

AU - Geng, Jumin

AU - Qin, Yiru

AU - Watson, David F.

AU - Lovell, Jonathan F.

PY - 2017/2/13

Y1 - 2017/2/13

N2 - Tetracarboxy porphyrins can be polymerized with polyethylene glycol (PEG) diamines to generate hydrogels with intense, near-infrared, and transdermal fluorescence following subcutaneous implantation. Here, we show that the high density porphyrins of the preformed polymer can be chelated with tin via simple incubation. Tin porphyrin hydrogels exhibited increasing emission intensities, ratios, and lifetimes from pH 1 to 10. Tin porphyrin hydrogel emission was strongly reversible and pH responsiveness was observed in the physiological range between pH 6 and pH 8. pH-sensitive emission was detected via noninvasive transdermal fluorescence imaging in vivo following subcutaneous implantation in mice.

AB - Tetracarboxy porphyrins can be polymerized with polyethylene glycol (PEG) diamines to generate hydrogels with intense, near-infrared, and transdermal fluorescence following subcutaneous implantation. Here, we show that the high density porphyrins of the preformed polymer can be chelated with tin via simple incubation. Tin porphyrin hydrogels exhibited increasing emission intensities, ratios, and lifetimes from pH 1 to 10. Tin porphyrin hydrogel emission was strongly reversible and pH responsiveness was observed in the physiological range between pH 6 and pH 8. pH-sensitive emission was detected via noninvasive transdermal fluorescence imaging in vivo following subcutaneous implantation in mice.

UR - https://www.scopus.com/pages/publications/85012273175

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AN - SCOPUS:85012273175

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SP - 562

EP - 567

JO - Biomacromolecules

JF - Biomacromolecules

IS - 2

ER -

Implantable Tin Porphyrin-PEG Hydrogels with pH-Responsive Fluorescence

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