Impaired Immune Response to Polysaccharides

Wim Timens; Sibrand Poppema; Ger T. Rijkers; Wietse Kuis; Elisabeth de Graeff-Meeder; Carla C.a.m. Peeters; Ben T.m. Zegers; Herbert B. Slade; Stanley A. Schwartz; Donna M. Ambrosino; George R. Siber; Barbara A. Chilmonczyk; Julia B. Jernberg; Robert W. Fineberg

doi:10.1056/NEJM198709243171315

Impaired Immune Response to Polysaccharides

Wim Timens
, Sibrand Poppema
, Ger T. Rijkers
, Wietse Kuis
, Elisabeth de Graeff-Meeder
, Carla C.a.m. Peeters
, Ben T.m. Zegers
, Herbert B. Slade
, Stanley A. Schwartz
, Donna M. Ambrosino
, George R. Siber
, Barbara A. Chilmonczyk
, Julia B. Jernberg
, Robert W. Fineberg

Medicine

University of Groningen
Utrecht University
University of Michigan, Ann Arbor
Dana-Farber Cancer Institute
The Foundation for Blood Research

Research output: Contribution to journal › Letter › peer-review

9 Scopus citations

Abstract

To the Editor: In a recent issue of the Journal (March 26), Ambrosino et al.¹ reported on a case characterized by selective absence of an antibody response to polysaccharide antigens, which caused recurrent sinopulmonary infections. As the authors state, the inability to produce an adequate immune response to polysaccharide antigens has also been observed in infants and young children. In addition, a similar inability and subsequent increased risk of overwhelming infections with polysaccharide-capsule–bearing bacteria has been observed in splenectomized patients. Polysaccharide antigens belong to the group of thymus-independent antigens, type 2 (TI-2). Splenectomized patients generally specifically respond poorly, or not…

Original language	English
Pages (from-to)	837-839
Number of pages	3
Journal	New England Journal of Medicine
Volume	317
Issue number	13
DOIs	https://doi.org/10.1056/NEJM198709243171315
State	Published - Sep 24 1987

Access to Document

10.1056/NEJM198709243171315

Cite this

Timens, W., Poppema, S., Rijkers, G. T., Kuis, W., de Graeff-Meeder, E., Peeters, C. C. A. M., Zegers, B. T. M., Slade, H. B., Schwartz, S. A., Ambrosino, D. M., Siber, G. R., Chilmonczyk, B. A., Jernberg, J. B., & Fineberg, R. W. (1987). Impaired Immune Response to Polysaccharides. New England Journal of Medicine, 317(13), 837-839. https://doi.org/10.1056/NEJM198709243171315

@article{a6e0c4a636584af1b4d13c1806936af7,

title = "Impaired Immune Response to Polysaccharides",

abstract = "To the Editor: In a recent issue of the Journal (March 26), Ambrosino et al.1 reported on a case characterized by selective absence of an antibody response to polysaccharide antigens, which caused recurrent sinopulmonary infections. As the authors state, the inability to produce an adequate immune response to polysaccharide antigens has also been observed in infants and young children. In addition, a similar inability and subsequent increased risk of overwhelming infections with polysaccharide-capsule{\textendash}bearing bacteria has been observed in splenectomized patients. Polysaccharide antigens belong to the group of thymus-independent antigens, type 2 (TI-2). Splenectomized patients generally specifically respond poorly, or not…",

author = "Wim Timens and Sibrand Poppema and Rijkers, \{Ger T.\} and Wietse Kuis and \{de Graeff-Meeder\}, Elisabeth and Peeters, \{Carla C.a.m.\} and Zegers, \{Ben T.m.\} and Slade, \{Herbert B.\} and Schwartz, \{Stanley A.\} and Ambrosino, \{Donna M.\} and Siber, \{George R.\} and Chilmonczyk, \{Barbara A.\} and Jernberg, \{Julia B.\} and Fineberg, \{Robert W.\}",

year = "1987",

month = sep,

day = "24",

doi = "10.1056/NEJM198709243171315",

language = "English",

volume = "317",

pages = "837--839",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

number = "13",

}

TY - JOUR

T1 - Impaired Immune Response to Polysaccharides

AU - Timens, Wim

AU - Poppema, Sibrand

AU - Rijkers, Ger T.

AU - Kuis, Wietse

AU - de Graeff-Meeder, Elisabeth

AU - Peeters, Carla C.a.m.

AU - Zegers, Ben T.m.

AU - Slade, Herbert B.

AU - Schwartz, Stanley A.

AU - Ambrosino, Donna M.

AU - Siber, George R.

AU - Chilmonczyk, Barbara A.

AU - Jernberg, Julia B.

AU - Fineberg, Robert W.

PY - 1987/9/24

Y1 - 1987/9/24

N2 - To the Editor: In a recent issue of the Journal (March 26), Ambrosino et al.1 reported on a case characterized by selective absence of an antibody response to polysaccharide antigens, which caused recurrent sinopulmonary infections. As the authors state, the inability to produce an adequate immune response to polysaccharide antigens has also been observed in infants and young children. In addition, a similar inability and subsequent increased risk of overwhelming infections with polysaccharide-capsule–bearing bacteria has been observed in splenectomized patients. Polysaccharide antigens belong to the group of thymus-independent antigens, type 2 (TI-2). Splenectomized patients generally specifically respond poorly, or not…

AB - To the Editor: In a recent issue of the Journal (March 26), Ambrosino et al.1 reported on a case characterized by selective absence of an antibody response to polysaccharide antigens, which caused recurrent sinopulmonary infections. As the authors state, the inability to produce an adequate immune response to polysaccharide antigens has also been observed in infants and young children. In addition, a similar inability and subsequent increased risk of overwhelming infections with polysaccharide-capsule–bearing bacteria has been observed in splenectomized patients. Polysaccharide antigens belong to the group of thymus-independent antigens, type 2 (TI-2). Splenectomized patients generally specifically respond poorly, or not…

UR - https://www.scopus.com/pages/publications/0023226806

U2 - 10.1056/NEJM198709243171315

DO - 10.1056/NEJM198709243171315

M3 - Letter

C2 - 3627203

AN - SCOPUS:0023226806

SN - 0028-4793

VL - 317

SP - 837

EP - 839

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 13

ER -

Impaired Immune Response to Polysaccharides

Abstract

Access to Document

Other files and links

Fingerprint

Cite this