Abstract
Opsonic antibody activity against Moraxella catarrhalis was determined in sera from children with otitis media. The antibody was determined with a new assay utilizing outer membrane antigen-coated latex beads. Antigen-coated beads opsonized in heat-inactivated pooled human serum phagocytosed 47.5 ± 36.1 beads per 100 neutrophils compared to 15.6 ± 10.2 beads per 100 neutrophils opsonized in hypogammaglobulinemic serum (p < .025). Antigen-coated beads opsonized in homologous sera from 11 children with M catarrhalis otitis media demonstrated increased opsonic activity in convalescent sera (34.6 ± 27.1) compared to acute sera (15.5 ± 6.7;p< .05). These data suggest that infection with M catarrhalis is associated with the development of opsonic antibody.
| Original language | English |
|---|---|
| Pages (from-to) | 522-524 |
| Number of pages | 3 |
| Journal | Annals of Otology, Rhinology and Laryngology |
| Volume | 103 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1994 |
Keywords
- Moraxella Catarrhalis
- opsonic antibody
- otitis media
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