Imaging pancreatic cancer using surface-functionalized quantum dots

Jun Qian; Ken Tye Yong; Indrajit Roy; Tymish Y. Ohulchanskyy; Earl J. Bergey; Boon Hi Lee; Kenneth M. Tramposch; Sailing He; Anirban Maitra; Paras N. Prasad

doi:10.1021/jp070620n

Imaging pancreatic cancer using surface-functionalized quantum dots

Jun Qian
, Ken Tye Yong
, Indrajit Roy
, Tymish Y. Ohulchanskyy
, Earl J. Bergey
, Boon Hi Lee
, Kenneth M. Tramposch
, Sailing He
, Anirban Maitra
, Paras N. Prasad

SUNY Buffalo
Zhejiang University
Johns Hopkins University

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

In this study, CdSe/CdS/ZnS quantum dots (QDs) were used as optical contrast agent for imaging pancreatic cancer cells in vitro using transferrin and anti-Claudin-4 as targeting ligands. CdSe/CdS/ZnS was chosen because the CdSe/CdS/ZnS QDs have better photoluminescence (PL) efficiency and stability than those of CdSe/ZnS. The transferrin-mediated targeting is demonstrated in both a cell-free coprecipitation assay as well as using in vitro confocal microscopy. Pancreatic cancer specific uptake is also demonstrated using the monoclonal antibody anti-Claudin-4. This targeted QD platform will be further modified for the purpose of developing as an early detection imaging tool for pancreatic cancer.

Original language	English
Pages (from-to)	6969-6972
Number of pages	4
Journal	Journal of Physical Chemistry B
Volume	111
Issue number	25
DOIs	https://doi.org/10.1021/jp070620n
State	Published - Jun 28 2007

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title = "Imaging pancreatic cancer using surface-functionalized quantum dots",

abstract = "In this study, CdSe/CdS/ZnS quantum dots (QDs) were used as optical contrast agent for imaging pancreatic cancer cells in vitro using transferrin and anti-Claudin-4 as targeting ligands. CdSe/CdS/ZnS was chosen because the CdSe/CdS/ZnS QDs have better photoluminescence (PL) efficiency and stability than those of CdSe/ZnS. The transferrin-mediated targeting is demonstrated in both a cell-free coprecipitation assay as well as using in vitro confocal microscopy. Pancreatic cancer specific uptake is also demonstrated using the monoclonal antibody anti-Claudin-4. This targeted QD platform will be further modified for the purpose of developing as an early detection imaging tool for pancreatic cancer.",

author = "Jun Qian and Yong, \{Ken Tye\} and Indrajit Roy and Ohulchanskyy, \{Tymish Y.\} and Bergey, \{Earl J.\} and Lee, \{Boon Hi\} and Tramposch, \{Kenneth M.\} and Sailing He and Anirban Maitra and Prasad, \{Paras N.\}",

year = "2007",

month = jun,

day = "28",

doi = "10.1021/jp070620n",

language = "English",

volume = "111",

pages = "6969--6972",

journal = "Journal of Physical Chemistry B",

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TY - JOUR

T1 - Imaging pancreatic cancer using surface-functionalized quantum dots

AU - Qian, Jun

AU - Yong, Ken Tye

AU - Roy, Indrajit

AU - Ohulchanskyy, Tymish Y.

AU - Bergey, Earl J.

AU - Lee, Boon Hi

AU - Tramposch, Kenneth M.

AU - He, Sailing

AU - Maitra, Anirban

AU - Prasad, Paras N.

PY - 2007/6/28

Y1 - 2007/6/28

N2 - In this study, CdSe/CdS/ZnS quantum dots (QDs) were used as optical contrast agent for imaging pancreatic cancer cells in vitro using transferrin and anti-Claudin-4 as targeting ligands. CdSe/CdS/ZnS was chosen because the CdSe/CdS/ZnS QDs have better photoluminescence (PL) efficiency and stability than those of CdSe/ZnS. The transferrin-mediated targeting is demonstrated in both a cell-free coprecipitation assay as well as using in vitro confocal microscopy. Pancreatic cancer specific uptake is also demonstrated using the monoclonal antibody anti-Claudin-4. This targeted QD platform will be further modified for the purpose of developing as an early detection imaging tool for pancreatic cancer.

AB - In this study, CdSe/CdS/ZnS quantum dots (QDs) were used as optical contrast agent for imaging pancreatic cancer cells in vitro using transferrin and anti-Claudin-4 as targeting ligands. CdSe/CdS/ZnS was chosen because the CdSe/CdS/ZnS QDs have better photoluminescence (PL) efficiency and stability than those of CdSe/ZnS. The transferrin-mediated targeting is demonstrated in both a cell-free coprecipitation assay as well as using in vitro confocal microscopy. Pancreatic cancer specific uptake is also demonstrated using the monoclonal antibody anti-Claudin-4. This targeted QD platform will be further modified for the purpose of developing as an early detection imaging tool for pancreatic cancer.

UR - https://www.scopus.com/pages/publications/34547367172

U2 - 10.1021/jp070620n

DO - 10.1021/jp070620n

M3 - Article

AN - SCOPUS:34547367172

SN - 1520-6106

VL - 111

SP - 6969

EP - 6972

JO - Journal of Physical Chemistry B

JF - Journal of Physical Chemistry B

IS - 25

ER -

Imaging pancreatic cancer using surface-functionalized quantum dots

Abstract

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