Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe

Wan Sun; Jing Xue Cui; Le Le Ma; Zhong Lin Lu; Bing Gong; Lan He; Ruibing Wang

doi:10.1039/c8an01643g

Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe

Wan Sun
, Jing Xue Cui
, Le Le Ma
, Zhong Lin Lu
, Bing Gong
, Lan He
, Ruibing Wang

Chemistry

Beijing Normal University
National Institutes for Food and Drug Control
University of Macau

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A two-photon fluorescent probe, TP-2Bz, was designed and synthesized and it exhibited good targeting capabilities toward cell nuclei. In particular, TP-2Bz demonstrated a high selectivity to both G-quadruplex DNA and viscosity inside the nucleus with significant ratiometric enhancement in fluorescence, providing a specific, versatile imaging tool for analyzing the viscosity and G-quadruplex DNA in living cells.

Original language	English
Pages (from-to)	5799-5804
Number of pages	6
Journal	Analyst
Volume	143
Issue number	23
DOIs	https://doi.org/10.1039/c8an01643g
State	Published - Dec 7 2018

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title = "Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe",

abstract = "A two-photon fluorescent probe, TP-2Bz, was designed and synthesized and it exhibited good targeting capabilities toward cell nuclei. In particular, TP-2Bz demonstrated a high selectivity to both G-quadruplex DNA and viscosity inside the nucleus with significant ratiometric enhancement in fluorescence, providing a specific, versatile imaging tool for analyzing the viscosity and G-quadruplex DNA in living cells.",

author = "Wan Sun and Cui, \{Jing Xue\} and Ma, \{Le Le\} and Lu, \{Zhong Lin\} and Bing Gong and Lan He and Ruibing Wang",

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T1 - Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe

AU - Sun, Wan

AU - Cui, Jing Xue

AU - Ma, Le Le

AU - Lu, Zhong Lin

AU - Gong, Bing

AU - He, Lan

AU - Wang, Ruibing

PY - 2018/12/7

Y1 - 2018/12/7

N2 - A two-photon fluorescent probe, TP-2Bz, was designed and synthesized and it exhibited good targeting capabilities toward cell nuclei. In particular, TP-2Bz demonstrated a high selectivity to both G-quadruplex DNA and viscosity inside the nucleus with significant ratiometric enhancement in fluorescence, providing a specific, versatile imaging tool for analyzing the viscosity and G-quadruplex DNA in living cells.

AB - A two-photon fluorescent probe, TP-2Bz, was designed and synthesized and it exhibited good targeting capabilities toward cell nuclei. In particular, TP-2Bz demonstrated a high selectivity to both G-quadruplex DNA and viscosity inside the nucleus with significant ratiometric enhancement in fluorescence, providing a specific, versatile imaging tool for analyzing the viscosity and G-quadruplex DNA in living cells.

UR - https://www.scopus.com/pages/publications/85056598135

U2 - 10.1039/c8an01643g

DO - 10.1039/c8an01643g

M3 - Article

C2 - 30357116

AN - SCOPUS:85056598135

SN - 0003-2654

VL - 143

SP - 5799

EP - 5804

JO - Analyst

JF - Analyst

IS - 23

ER -

Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe

Abstract

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