Ibuprofen

Conor Young; William Eggleston

doi:10.1016/B978-0-12-824315-2.00727-2

Ibuprofen

Conor Young
, William Eggleston

Department of Emergency Medicine

State University of New York Binghamton University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Ibuprofen is a common over-the-counter analgesic with nonsteroidal anti-inflammatory properties. While most overdoses cause only mild gastrointestinal upset, massive overdoses (>200mgkg⁻¹) can be life-threatening. Severe toxicity may present with altered mental status, metabolic acidosis, renal insufficiency or failure, and seizures. Ibuprofen also exhibits mitochondrial toxicity in massive overdose. Ibuprofen is often combined with other over-the-counter medications including antihistamines and decongestants; therefore, patients are at risk of developing multiple toxicities. Management of acute and chronic ibuprofen overdose is primarily supportive care.

Original language	English
Title of host publication	Encyclopedia of Toxicology, Fourth Edition
Subtitle of host publication	Volume 1-9
Publisher	Elsevier
Pages	V5-443-V5-447
Volume	5
ISBN (Electronic)	9780128243152
DOIs	https://doi.org/10.1016/B978-0-12-824315-2.00727-2
State	Published - Jan 1 2023

Keywords

Analgesic
Anti-inflammatory
Ibuprofen
Nonsteroidal
NSAID
Pain
Pharmaceutical and personal care products (PPCPs)
Propionic acid

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10.1016/B978-0-12-824315-2.00727-2

Cite this

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title = "Ibuprofen",

abstract = "Ibuprofen is a common over-the-counter analgesic with nonsteroidal anti-inflammatory properties. While most overdoses cause only mild gastrointestinal upset, massive overdoses (>200mgkg−1) can be life-threatening. Severe toxicity may present with altered mental status, metabolic acidosis, renal insufficiency or failure, and seizures. Ibuprofen also exhibits mitochondrial toxicity in massive overdose. Ibuprofen is often combined with other over-the-counter medications including antihistamines and decongestants; therefore, patients are at risk of developing multiple toxicities. Management of acute and chronic ibuprofen overdose is primarily supportive care.",

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AU - Eggleston, William

PY - 2023/1/1

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N2 - Ibuprofen is a common over-the-counter analgesic with nonsteroidal anti-inflammatory properties. While most overdoses cause only mild gastrointestinal upset, massive overdoses (>200mgkg−1) can be life-threatening. Severe toxicity may present with altered mental status, metabolic acidosis, renal insufficiency or failure, and seizures. Ibuprofen also exhibits mitochondrial toxicity in massive overdose. Ibuprofen is often combined with other over-the-counter medications including antihistamines and decongestants; therefore, patients are at risk of developing multiple toxicities. Management of acute and chronic ibuprofen overdose is primarily supportive care.

AB - Ibuprofen is a common over-the-counter analgesic with nonsteroidal anti-inflammatory properties. While most overdoses cause only mild gastrointestinal upset, massive overdoses (>200mgkg−1) can be life-threatening. Severe toxicity may present with altered mental status, metabolic acidosis, renal insufficiency or failure, and seizures. Ibuprofen also exhibits mitochondrial toxicity in massive overdose. Ibuprofen is often combined with other over-the-counter medications including antihistamines and decongestants; therefore, patients are at risk of developing multiple toxicities. Management of acute and chronic ibuprofen overdose is primarily supportive care.

KW - Analgesic

KW - Anti-inflammatory

KW - Ibuprofen

KW - Nonsteroidal

KW - NSAID

KW - Pain

KW - Pharmaceutical and personal care products (PPCPs)

KW - Propionic acid

UR - https://www.scopus.com/pages/publications/85188050772

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DO - 10.1016/B978-0-12-824315-2.00727-2

M3 - Chapter

AN - SCOPUS:85188050772

VL - 5

SP - V5-443-V5-447

BT - Encyclopedia of Toxicology, Fourth Edition

PB - Elsevier

ER -

Ibuprofen

Abstract

Keywords

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