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Hypo/hyperglycemic constrained design of IV insulin control for type 1 diabetic patients with meal and initial condition uncertainties using sequential quadratic programming

  • SUNY Buffalo

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The focus of this paper is on the development of an open loop controller for type 1 diabetic patients which is robust to meal and initial condition uncertainties in the presence of hypoand hyperglycemic constraints. Bernstein polynomials are used to parametrize the evolving uncertain blood-glucose. The unique bounding properties of these polynomials are then used to enforce the desired glycemic constraints. A convex optimization problem is posed in the perturbation space of the model and is solved repeatedly to sequentially converge on a sub-optimal solution. The proposed approach is demonstrated on the classic Bergman model for Type 1 diabetic patients.

Original languageEnglish
Title of host publicationBiomedical and Biotechnology Engineering
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791852026
DOIs
StatePublished - 2018
EventASME 2018 International Mechanical Engineering Congress and Exposition, IMECE 2018 - Pittsburgh, United States
Duration: Nov 9 2018 → Nov 15 2018

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume3

Conference

ConferenceASME 2018 International Mechanical Engineering Congress and Exposition, IMECE 2018
Country/TerritoryUnited States
CityPittsburgh
Period11/9/18 → 11/15/18

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