Hyperbaric pressure of 51 atmospheres is without effect on the depression of oxygen uptake in kidney tissue culture produced by halothane

Peter J. Cohen; Elliott Bedows; Michael J. Brabec; Paul R. Knight

doi:10.1016/0024-3205(85)90133-X

Hyperbaric pressure of 51 atmospheres is without effect on the depression of oxygen uptake in kidney tissue culture produced by halothane

Peter J. Cohen
, Elliott Bedows
, Michael J. Brabec
, Paul R. Knight

Department of Anesthesiology

University of Michigan, Ann Arbor

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Although anesthetized animals are awakened when subjected to increased pressure, compression does not result in antagonism of all phenomena associated with these drugs. It has recently been demonstrated that halothane's inhibition of respiration of isolated rat liver mitochondria is not reversed by hydraulic compression to 51 atmospheres. In order to determine whether this phenomenon can be extrapolated to the whole cell, we have investigated the effect of hydraulic compression of intact renal cells equilibrated with halothane, and conclude that pressure does not overcome the inhibitory effect of this anesthetic.

Original language	English
Pages (from-to)	1221-1224
Number of pages	4
Journal	Life Sciences
Volume	37
Issue number	13
DOIs	https://doi.org/10.1016/0024-3205(85)90133-X
State	Published - Sep 30 1985

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title = "Hyperbaric pressure of 51 atmospheres is without effect on the depression of oxygen uptake in kidney tissue culture produced by halothane",

abstract = "Although anesthetized animals are awakened when subjected to increased pressure, compression does not result in antagonism of all phenomena associated with these drugs. It has recently been demonstrated that halothane's inhibition of respiration of isolated rat liver mitochondria is not reversed by hydraulic compression to 51 atmospheres. In order to determine whether this phenomenon can be extrapolated to the whole cell, we have investigated the effect of hydraulic compression of intact renal cells equilibrated with halothane, and conclude that pressure does not overcome the inhibitory effect of this anesthetic.",

author = "Cohen, \{Peter J.\} and Elliott Bedows and Brabec, \{Michael J.\} and Knight, \{Paul R.\}",

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AU - Cohen, Peter J.

AU - Bedows, Elliott

AU - Brabec, Michael J.

AU - Knight, Paul R.

PY - 1985/9/30

Y1 - 1985/9/30

N2 - Although anesthetized animals are awakened when subjected to increased pressure, compression does not result in antagonism of all phenomena associated with these drugs. It has recently been demonstrated that halothane's inhibition of respiration of isolated rat liver mitochondria is not reversed by hydraulic compression to 51 atmospheres. In order to determine whether this phenomenon can be extrapolated to the whole cell, we have investigated the effect of hydraulic compression of intact renal cells equilibrated with halothane, and conclude that pressure does not overcome the inhibitory effect of this anesthetic.

AB - Although anesthetized animals are awakened when subjected to increased pressure, compression does not result in antagonism of all phenomena associated with these drugs. It has recently been demonstrated that halothane's inhibition of respiration of isolated rat liver mitochondria is not reversed by hydraulic compression to 51 atmospheres. In order to determine whether this phenomenon can be extrapolated to the whole cell, we have investigated the effect of hydraulic compression of intact renal cells equilibrated with halothane, and conclude that pressure does not overcome the inhibitory effect of this anesthetic.

UR - https://www.scopus.com/pages/publications/0022367893

U2 - 10.1016/0024-3205(85)90133-X

DO - 10.1016/0024-3205(85)90133-X

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ER -

Hyperbaric pressure of 51 atmospheres is without effect on the depression of oxygen uptake in kidney tissue culture produced by halothane

Abstract

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