Human osteoblast stimulation by sera from paraplegic patients with heterotopic ossification

M. H.J. Kurer; M. A. Khoker; P. Dandona

doi:10.1038/sc.1992.48

Human osteoblast stimulation by sera from paraplegic patients with heterotopic ossification

M. H.J. Kurer
, M. A. Khoker
, P. Dandona

Medicine

Royal National Orthopaedic Hospital NHS Trust
Royal Free London NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

The pathophysiology of heterotopic periarticular ossification is not understood. Though local agents may be responsible, factors present in the serum may be contributory. Sera from 4 paraplegic patients with heterotopic ossification and 4 ‘normal’ paraplegics were incubated with human osteoblasts in tissue culture and their metabolic acitivy was measured quantitatively. There were significantly greater levels of osteoblast stimulating factors present in the sera of ossifying patients, (p < 0.01). These factors may contribute to the pathogenesis of heterotopic ossification.

Original language	English
Pages (from-to)	165-168
Number of pages	4
Journal	Paraplegia
Volume	30
Issue number	3
DOIs	https://doi.org/10.1038/sc.1992.48
State	Published - Mar 1992

Keywords

Heterotopic ossification
Hormone
Osteoblast
Paraplegia

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10.1038/sc.1992.48

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title = "Human osteoblast stimulation by sera from paraplegic patients with heterotopic ossification",

abstract = "The pathophysiology of heterotopic periarticular ossification is not understood. Though local agents may be responsible, factors present in the serum may be contributory. Sera from 4 paraplegic patients with heterotopic ossification and 4 {\textquoteleft}normal{\textquoteright} paraplegics were incubated with human osteoblasts in tissue culture and their metabolic acitivy was measured quantitatively. There were significantly greater levels of osteoblast stimulating factors present in the sera of ossifying patients, (p < 0.01). These factors may contribute to the pathogenesis of heterotopic ossification.",

keywords = "Heterotopic ossification, Hormone, Osteoblast, Paraplegia",

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AU - Khoker, M. A.

AU - Dandona, P.

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N2 - The pathophysiology of heterotopic periarticular ossification is not understood. Though local agents may be responsible, factors present in the serum may be contributory. Sera from 4 paraplegic patients with heterotopic ossification and 4 ‘normal’ paraplegics were incubated with human osteoblasts in tissue culture and their metabolic acitivy was measured quantitatively. There were significantly greater levels of osteoblast stimulating factors present in the sera of ossifying patients, (p < 0.01). These factors may contribute to the pathogenesis of heterotopic ossification.

AB - The pathophysiology of heterotopic periarticular ossification is not understood. Though local agents may be responsible, factors present in the serum may be contributory. Sera from 4 paraplegic patients with heterotopic ossification and 4 ‘normal’ paraplegics were incubated with human osteoblasts in tissue culture and their metabolic acitivy was measured quantitatively. There were significantly greater levels of osteoblast stimulating factors present in the sera of ossifying patients, (p < 0.01). These factors may contribute to the pathogenesis of heterotopic ossification.

KW - Heterotopic ossification

KW - Hormone

KW - Osteoblast

KW - Paraplegia

UR - https://www.scopus.com/pages/publications/0026525867

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ER -

Human osteoblast stimulation by sera from paraplegic patients with heterotopic ossification

Abstract

Keywords

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