Human immunodeficiency virus infection of fibroblasts of dental pulp in seropositive patients

Michael Glick; Martin Trope; Omar Bagasra; Michael E. Pliskin

doi:10.1016/0030-4220(91)90284-J

Human immunodeficiency virus infection of fibroblasts of dental pulp in seropositive patients

Michael Glick
, Martin Trope
, Omar Bagasra
, Michael E. Pliskin

Oral Diagnostic Sciences Administration

Temple University

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Presence of human immunodeficiency virus (HIV) within noninflamed human dental pulps was documented by polymerase chain reaction assays in 11 of 12 pulps from HIV-seropositive patients. The purpose of the present study was to determine the cellular location of HIV in vivo within these tissues by means of in situ hybridization. Results of the in situ hybridization indicated HIV within fibroblasts of the pulp. These results are especially relevant because fibroblasts lack the CD4 receptor thought necessary for in vivo infection with HIV. These results suggest the fibroblast as a possible reservoir for HIV in the body.

Original language	English
Pages (from-to)	733-736
Number of pages	4
Journal	Oral Surgery Oral Medicine and Oral Pathology
Volume	71
Issue number	6
DOIs	https://doi.org/10.1016/0030-4220(91)90284-J
State	Published - Jun 1991

Access to Document

10.1016/0030-4220(91)90284-J

Cite this

@article{7ca0f5a81fb14f769555bb56a3b5e853,

title = "Human immunodeficiency virus infection of fibroblasts of dental pulp in seropositive patients",

abstract = "Presence of human immunodeficiency virus (HIV) within noninflamed human dental pulps was documented by polymerase chain reaction assays in 11 of 12 pulps from HIV-seropositive patients. The purpose of the present study was to determine the cellular location of HIV in vivo within these tissues by means of in situ hybridization. Results of the in situ hybridization indicated HIV within fibroblasts of the pulp. These results are especially relevant because fibroblasts lack the CD4 receptor thought necessary for in vivo infection with HIV. These results suggest the fibroblast as a possible reservoir for HIV in the body.",

author = "Michael Glick and Martin Trope and Omar Bagasra and Pliskin, \{Michael E.\}",

year = "1991",

month = jun,

doi = "10.1016/0030-4220(91)90284-J",

language = "English",

volume = "71",

pages = "733--736",

journal = "Oral Surgery Oral Medicine and Oral Pathology",

issn = "0030-4220",

publisher = "Mosby-Year Book Inc.",

number = "6",

}

TY - JOUR

T1 - Human immunodeficiency virus infection of fibroblasts of dental pulp in seropositive patients

AU - Glick, Michael

AU - Trope, Martin

AU - Bagasra, Omar

AU - Pliskin, Michael E.

PY - 1991/6

Y1 - 1991/6

N2 - Presence of human immunodeficiency virus (HIV) within noninflamed human dental pulps was documented by polymerase chain reaction assays in 11 of 12 pulps from HIV-seropositive patients. The purpose of the present study was to determine the cellular location of HIV in vivo within these tissues by means of in situ hybridization. Results of the in situ hybridization indicated HIV within fibroblasts of the pulp. These results are especially relevant because fibroblasts lack the CD4 receptor thought necessary for in vivo infection with HIV. These results suggest the fibroblast as a possible reservoir for HIV in the body.

AB - Presence of human immunodeficiency virus (HIV) within noninflamed human dental pulps was documented by polymerase chain reaction assays in 11 of 12 pulps from HIV-seropositive patients. The purpose of the present study was to determine the cellular location of HIV in vivo within these tissues by means of in situ hybridization. Results of the in situ hybridization indicated HIV within fibroblasts of the pulp. These results are especially relevant because fibroblasts lack the CD4 receptor thought necessary for in vivo infection with HIV. These results suggest the fibroblast as a possible reservoir for HIV in the body.

UR - https://www.scopus.com/pages/publications/0025837908

U2 - 10.1016/0030-4220(91)90284-J

DO - 10.1016/0030-4220(91)90284-J

M3 - Article

C2 - 1676502

AN - SCOPUS:0025837908

SN - 0030-4220

VL - 71

SP - 733

EP - 736

JO - Oral Surgery Oral Medicine and Oral Pathology

JF - Oral Surgery Oral Medicine and Oral Pathology

IS - 6

ER -

Human immunodeficiency virus infection of fibroblasts of dental pulp in seropositive patients

Abstract

Access to Document

Other files and links

Fingerprint

Cite this