Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney

Mark D. Parker; Elizabeth P. Ourmozdi; Michael J.A. Tanner

doi:10.1006/bbrc.2001.4692

Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney

Mark D. Parker
, Elizabeth P. Ourmozdi
, Michael J.A. Tanner

Physiology and Biophysics

University of Bristol

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

We report the cloning, characterization, and chromosomal localization of two novel human members of the bicarbonate transporter superfamily, BTR1 (Bicarbonate Transporter Related protein-1) and AE4 (Anion Exchange protein 4). BTR1 is a novel mammalian protein. The BTR1 gene maps to chromosome 20p12 and encodes a 100 kDa protein predominantly expressed in the kidney, salivary glands, testis, thyroid glands, and trachea. The AE4 gene maps to chromosome 5q23-31 and encodes a 104 kDa protein expressed mainly in the kidney. Human AE4 shares 84% identity with the recently reported rabbit AE4, a sodium independent, Cl^-/HCO₃^- exchanger located on the apical membrane of β-intercalated kidney cells.

Original language	English
Pages (from-to)	1103-1109
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	282
Issue number	5
DOIs	https://doi.org/10.1006/bbrc.2001.4692
State	Published - 2001

Keywords

Anion exchanger
Bicarbonate transport
Kidney
NBC
PH
Salivary
Thyroid
Trachea
β-intercalated

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10.1006/bbrc.2001.4692

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title = "Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney",

abstract = "We report the cloning, characterization, and chromosomal localization of two novel human members of the bicarbonate transporter superfamily, BTR1 (Bicarbonate Transporter Related protein-1) and AE4 (Anion Exchange protein 4). BTR1 is a novel mammalian protein. The BTR1 gene maps to chromosome 20p12 and encodes a 100 kDa protein predominantly expressed in the kidney, salivary glands, testis, thyroid glands, and trachea. The AE4 gene maps to chromosome 5q23-31 and encodes a 104 kDa protein expressed mainly in the kidney. Human AE4 shares 84\% identity with the recently reported rabbit AE4, a sodium independent, Cl-/HCO3- exchanger located on the apical membrane of β-intercalated kidney cells.",

keywords = "Anion exchanger, Bicarbonate transport, Kidney, NBC, PH, Salivary, Thyroid, Trachea, β-intercalated",

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year = "2001",

doi = "10.1006/bbrc.2001.4692",

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journal = "Biochemical and Biophysical Research Communications",

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T1 - Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney

AU - Parker, Mark D.

AU - Ourmozdi, Elizabeth P.

AU - Tanner, Michael J.A.

PY - 2001

Y1 - 2001

N2 - We report the cloning, characterization, and chromosomal localization of two novel human members of the bicarbonate transporter superfamily, BTR1 (Bicarbonate Transporter Related protein-1) and AE4 (Anion Exchange protein 4). BTR1 is a novel mammalian protein. The BTR1 gene maps to chromosome 20p12 and encodes a 100 kDa protein predominantly expressed in the kidney, salivary glands, testis, thyroid glands, and trachea. The AE4 gene maps to chromosome 5q23-31 and encodes a 104 kDa protein expressed mainly in the kidney. Human AE4 shares 84% identity with the recently reported rabbit AE4, a sodium independent, Cl-/HCO3- exchanger located on the apical membrane of β-intercalated kidney cells.

AB - We report the cloning, characterization, and chromosomal localization of two novel human members of the bicarbonate transporter superfamily, BTR1 (Bicarbonate Transporter Related protein-1) and AE4 (Anion Exchange protein 4). BTR1 is a novel mammalian protein. The BTR1 gene maps to chromosome 20p12 and encodes a 100 kDa protein predominantly expressed in the kidney, salivary glands, testis, thyroid glands, and trachea. The AE4 gene maps to chromosome 5q23-31 and encodes a 104 kDa protein expressed mainly in the kidney. Human AE4 shares 84% identity with the recently reported rabbit AE4, a sodium independent, Cl-/HCO3- exchanger located on the apical membrane of β-intercalated kidney cells.

KW - Anion exchanger

KW - Bicarbonate transport

KW - Kidney

KW - NBC

KW - PH

KW - Salivary

KW - Thyroid

KW - Trachea

KW - β-intercalated

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U2 - 10.1006/bbrc.2001.4692

DO - 10.1006/bbrc.2001.4692

M3 - Article

C2 - 11302728

AN - SCOPUS:0034801435

SN - 0006-291X

VL - 282

SP - 1103

EP - 1109

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 5

ER -

Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney

Abstract

Keywords

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