@inbook{cc1c34138e584d94b96dc3faec4d81fb,
title = "Human Brain Organoid Platform for Neuroengineering Optical Theranostics in Neonatal Sepsis",
abstract = "Early-onset neonatal sepsis can increase the risk of hypoxic-ischemic encephalopathy (HIE) that can worsen the patient{\textquoteright}s prognosis. We investigated neurometabolic coupling (NMC) in five full-term neonates with HIE and sepsis that was found lower than the other five with HIE only. We hypothesized that transcranial photobiomodulation might upregulate cerebral oxygen metabolism, which may restore NMC. We developed a human brain organoid platform to evaluate the effects of photobiomodulation around 810 nm on the Cytochrome-C Oxidase (CCO) activity and electrophysiology. We found that 10 min of photobiomodulation increased CCO activity, pH, and temperature while decreased the spectral exponent in 1–40 Hz from electrophysiology data. For future work, it is postulated that photobiomodulation at \textasciitilde{}810 nm may ameliorate metabolic acidosis and dysfunctional NMC in neonatal sepsis, thereby reducing the risk of HIE transition.",
author = "Karanth, \{Sneha S.\} and Radhika Mujumdar and Sahoo, \{Jagdish P.\} and Abhijit Das and Stachowiak, \{Michal K.\} and Anirban Dutta",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.",
year = "2022",
doi = "10.1007/978-3-030-70316-5\_120",
language = "English",
series = "Biosystems and Biorobotics",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "753--757",
booktitle = "Biosystems and Biorobotics",
address = "Germany",
}