Abstract
A high‐pressure liquid chromatographic method for the sensitive, rapid, and specific determination of sulfapyridine and its N‐acetyl derivative in plasma and saliva was developed. A cyano‐bonded, reversed‐phase, high efficiency column was used. The system detected these sulfonamides in serum to 0.25 mg/liter and within only 6 min. Sulfapyridine was separated from its acetyl derivative with little interference from other drugs. The assay reproducibility was with 3%. The assay was highly useful for routine monitoring of patients receiving sulfasalazine for inflammatory bowel disease.
| Original language | English |
|---|---|
| Pages (from-to) | 1250-1253 |
| Number of pages | 4 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 67 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1978 |
Keywords
- Dermatitis suppressants—sulfapyridine and acetyl metabolite, high‐performance liquid chromatographic analyses in biological fluids
- High‐performance liquid. chromatography—analyses, sulfapyridine and acetyl metabolite in biological fluids
- Sulfapyridine and acetyl metabolite—high‐performance liquid chromatographic analyses in biological fluids
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