Heroin reward is dependent on a dopaminergic substrate

Michael A. Bozarth; Roy A. Wise

doi:10.1016/0024-3205(81)90519-1

Heroin reward is dependent on a dopaminergic substrate

Michael A. Bozarth
, Roy A. Wise

Psychology

Concordia University

Research output: Contribution to journal › Article › peer-review

283 Scopus citations

Abstract

The rewarding property of heroin was blocked by pretreatment with either naloxone or pimozide, suggesting that this opiate-receptor mediated effect is dependent on a dopaminergic substrate. The involvement of a dopaminergic mechanism in this effect supports the notion that opiates and other sources of reward activate a similar neural substrate.

Original language	English
Pages (from-to)	1881-1886
Number of pages	6
Journal	Life Sciences
Volume	29
Issue number	18
DOIs	https://doi.org/10.1016/0024-3205(81)90519-1
State	Published - Nov 2 1981

Access to Document

10.1016/0024-3205(81)90519-1

Cite this

@article{091e8eaeeb1745c29acc196879dd6dd7,

title = "Heroin reward is dependent on a dopaminergic substrate",

abstract = "The rewarding property of heroin was blocked by pretreatment with either naloxone or pimozide, suggesting that this opiate-receptor mediated effect is dependent on a dopaminergic substrate. The involvement of a dopaminergic mechanism in this effect supports the notion that opiates and other sources of reward activate a similar neural substrate.",

author = "Bozarth, \{Michael A.\} and Wise, \{Roy A.\}",

year = "1981",

month = nov,

day = "2",

doi = "10.1016/0024-3205(81)90519-1",

language = "English",

volume = "29",

pages = "1881--1886",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "18",

}

TY - JOUR

T1 - Heroin reward is dependent on a dopaminergic substrate

AU - Bozarth, Michael A.

AU - Wise, Roy A.

PY - 1981/11/2

Y1 - 1981/11/2

N2 - The rewarding property of heroin was blocked by pretreatment with either naloxone or pimozide, suggesting that this opiate-receptor mediated effect is dependent on a dopaminergic substrate. The involvement of a dopaminergic mechanism in this effect supports the notion that opiates and other sources of reward activate a similar neural substrate.

AB - The rewarding property of heroin was blocked by pretreatment with either naloxone or pimozide, suggesting that this opiate-receptor mediated effect is dependent on a dopaminergic substrate. The involvement of a dopaminergic mechanism in this effect supports the notion that opiates and other sources of reward activate a similar neural substrate.

UR - https://www.scopus.com/pages/publications/0019834709

U2 - 10.1016/0024-3205(81)90519-1

DO - 10.1016/0024-3205(81)90519-1

M3 - Article

C2 - 7311722

AN - SCOPUS:0019834709

SN - 0024-3205

VL - 29

SP - 1881

EP - 1886

JO - Life Sciences

JF - Life Sciences

IS - 18

ER -

Heroin reward is dependent on a dopaminergic substrate

Abstract

Access to Document

Other files and links

Fingerprint

Cite this