Hepatitis C Viral Kinetics. The Past, Present, and Future

Anushree Chatterjee; Patrick F. Smith; Alan S. Perelson

doi:10.1016/j.cld.2012.09.003

Hepatitis C Viral Kinetics. The Past, Present, and Future

Anushree Chatterjee
, Patrick F. Smith
, Alan S. Perelson

Pharmacy

Los Alamos National Laboratory
Center for Nonlinear Studies

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Mathematical modeling of hepatitis C viral kinetics has been an important tool in understanding hepatitis C virus (HCV) infection dynamics and in estimating crucial in vivo parameters characterizing the effectiveness of HCV therapy. Because of the introduction of direct-acting antiviral agents, there is a need to extend previous models so as to understand, characterize, and compare various new HCV treatment regimens. Here we review recent modeling efforts in this direction.

Original language	English
Pages (from-to)	13-26
Number of pages	14
Journal	Clinics in Liver Disease
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/j.cld.2012.09.003
State	Published - Feb 2013

Keywords

Direct-acting antiviral agents
Hepatitis C virus
Mathematical modeling
Protease inhibitors
Viral kinetics

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10.1016/j.cld.2012.09.003

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abstract = "Mathematical modeling of hepatitis C viral kinetics has been an important tool in understanding hepatitis C virus (HCV) infection dynamics and in estimating crucial in vivo parameters characterizing the effectiveness of HCV therapy. Because of the introduction of direct-acting antiviral agents, there is a need to extend previous models so as to understand, characterize, and compare various new HCV treatment regimens. Here we review recent modeling efforts in this direction.",

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AU - Perelson, Alan S.

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AB - Mathematical modeling of hepatitis C viral kinetics has been an important tool in understanding hepatitis C virus (HCV) infection dynamics and in estimating crucial in vivo parameters characterizing the effectiveness of HCV therapy. Because of the introduction of direct-acting antiviral agents, there is a need to extend previous models so as to understand, characterize, and compare various new HCV treatment regimens. Here we review recent modeling efforts in this direction.

KW - Direct-acting antiviral agents

KW - Hepatitis C virus

KW - Mathematical modeling

KW - Protease inhibitors

KW - Viral kinetics

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M3 - Review article

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Hepatitis C Viral Kinetics. The Past, Present, and Future

Abstract

Keywords

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