Abstract
A series of pyrimido-pyrimidine derivatives were tested for their effect on membrane fluidity-deformability of human red blood cells and on human platelet aggregation. These agents were also tested for their intracellular cAMP increasing activity and proliferation inhibitory activity in neoplastic cells. The order of activity was established and clinical implications discussed. Several derivatives are under study as antineoplastic agents.
| Original language | English |
|---|---|
| Pages (from-to) | 21-32 |
| Number of pages | 12 |
| Journal | Journal of Medicine |
| Volume | 27 |
| Issue number | 1-2 |
| State | Published - 1996 |
Keywords
- B16-melanoma
- cAMP
- cancer cells
- cellular proliferation
- hemorrheologic agents
- hemorrheology
- membrane fluidity
- MM47T-sarcoma
- neoplastic cells
- platelet aggregation
- platelets
- pyrimido-pyrimidines
- red blood cells
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