Abstract
Pentoxifylline (Trental ®) is metabolized by red blood cells and the liver into seven metabolites. Metabolites I and V have significant hemorrheologic effects. They are both similar to pentoxifylline in their activity on red blood cell membrane fluidity. Metabolite I is more active than pentoxifylline in inhibiting ADP-induced platelet aggregation. Metabolite V is more active than pentoxifylline in inhibiting epinephrine- induced platelet aggregation.
| Original language | English |
|---|---|
| Pages (from-to) | 65-75 |
| Number of pages | 11 |
| Journal | Journal of Medicine |
| Volume | 26 |
| Issue number | 1-2 |
| State | Published - 1995 |
Keywords
- Aspirin
- drug metabolites
- pentoxifylline
- platelet aggregation
- red blood cell deformability
- Trental®
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