Heme Biosynthesis

M. R. O'Brian

doi:10.1016/B978-012373944-5.00104-8

Heme Biosynthesis

M. R. O'Brian

Biochemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

Hemes are involved in many cellular processes in prokaryotes and eukaryotes. Whereas the classic role for heme is in respiration and oxygen metabolism, it is now known to play important roles in perception and signaling. The biosynthetic pathway leading to heme formation is, with a few interesting exceptions, well conserved and is controlled in accordance with cellular function. There has been significant progress in understanding the structures and catalytic mechanisms of the heme biosynthetic pathway enzymes over the last several years. In addition, the availability of whole genome sequences has shed light on the gaps in our understanding of heme biosynthesis in prokaryotes.

Original language	English
Title of host publication	Encyclopedia of Microbiology, Third Edition
Publisher	Elsevier
Pages	194-209
Number of pages	16
ISBN (Electronic)	9780123739445
DOIs	https://doi.org/10.1016/B978-012373944-5.00104-8
State	Published - Jan 1 2009

Keywords

AdoMet
ALA
eALAS
erythroid cell-specific
glutamate-1-semialdehyde
glutamyl-tRNA reductase
GSA
GTR
heme regulatory motif
HRM
iron response regulator
Irr
PBG
PCT
porphobilinogen
porphyria cutanea tarda
reactive oxygen species
ROS
S-adenosyl-l-methionine
S-adenosylmethionine
SAM
Sideroblastic X-linked anemia
XLSA
δ-aminolevulinic acid

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10.1016/B978-012373944-5.00104-8

Cite this

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title = "Heme Biosynthesis",

abstract = "Hemes are involved in many cellular processes in prokaryotes and eukaryotes. Whereas the classic role for heme is in respiration and oxygen metabolism, it is now known to play important roles in perception and signaling. The biosynthetic pathway leading to heme formation is, with a few interesting exceptions, well conserved and is controlled in accordance with cellular function. There has been significant progress in understanding the structures and catalytic mechanisms of the heme biosynthetic pathway enzymes over the last several years. In addition, the availability of whole genome sequences has shed light on the gaps in our understanding of heme biosynthesis in prokaryotes.",

keywords = "AdoMet, ALA, eALAS, erythroid cell-specific, glutamate-1-semialdehyde, glutamyl-tRNA reductase, GSA, GTR, heme regulatory motif, HRM, iron response regulator, Irr, PBG, PCT, porphobilinogen, porphyria cutanea tarda, reactive oxygen species, ROS, S-adenosyl-l-methionine, S-adenosylmethionine, SAM, Sideroblastic X-linked anemia, XLSA, δ-aminolevulinic acid",

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year = "2009",

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doi = "10.1016/B978-012373944-5.00104-8",

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T1 - Heme Biosynthesis

AU - O'Brian, M. R.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Hemes are involved in many cellular processes in prokaryotes and eukaryotes. Whereas the classic role for heme is in respiration and oxygen metabolism, it is now known to play important roles in perception and signaling. The biosynthetic pathway leading to heme formation is, with a few interesting exceptions, well conserved and is controlled in accordance with cellular function. There has been significant progress in understanding the structures and catalytic mechanisms of the heme biosynthetic pathway enzymes over the last several years. In addition, the availability of whole genome sequences has shed light on the gaps in our understanding of heme biosynthesis in prokaryotes.

AB - Hemes are involved in many cellular processes in prokaryotes and eukaryotes. Whereas the classic role for heme is in respiration and oxygen metabolism, it is now known to play important roles in perception and signaling. The biosynthetic pathway leading to heme formation is, with a few interesting exceptions, well conserved and is controlled in accordance with cellular function. There has been significant progress in understanding the structures and catalytic mechanisms of the heme biosynthetic pathway enzymes over the last several years. In addition, the availability of whole genome sequences has shed light on the gaps in our understanding of heme biosynthesis in prokaryotes.

KW - AdoMet

KW - ALA

KW - eALAS

KW - erythroid cell-specific

KW - glutamate-1-semialdehyde

KW - glutamyl-tRNA reductase

KW - GSA

KW - GTR

KW - heme regulatory motif

KW - HRM

KW - iron response regulator

KW - Irr

KW - PBG

KW - PCT

KW - porphobilinogen

KW - porphyria cutanea tarda

KW - reactive oxygen species

KW - ROS

KW - S-adenosyl-l-methionine

KW - S-adenosylmethionine

KW - SAM

KW - Sideroblastic X-linked anemia

KW - XLSA

KW - δ-aminolevulinic acid

UR - https://www.scopus.com/pages/publications/84867463236

U2 - 10.1016/B978-012373944-5.00104-8

DO - 10.1016/B978-012373944-5.00104-8

M3 - Chapter

AN - SCOPUS:84867463236

SP - 194

EP - 209

BT - Encyclopedia of Microbiology, Third Edition

PB - Elsevier

ER -

Heme Biosynthesis

Abstract

Keywords

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