Gut microbiota composition and relapse risk in pediatric MS: A pilot study

Helen Tremlett; Douglas W. Fadrosh; Ali A. Faruqi; Janace Hart; Shelly Roalstad; Jennifer Graves; Susan Lynch; Emmanuelle Waubant; Greg Aaen; Anita Belman; Leslie Benson; Charlie Casper; Tanuja Chitnis; Mark Gorman; Yolanda Harris; Lauren Krupp; Tim E. Lotze; Sabina Lulu; Jayne Ness; Cody Olsen; Erik Roan; Moses Rodriguez; John Rose; Timothy C. Simmons; Jan Mendelt Tillema; Wendy Weber; Bianca Weinstock-Guttman

doi:10.1016/j.jns.2016.02.042

Gut microbiota composition and relapse risk in pediatric MS: A pilot study

Helen Tremlett
, Douglas W. Fadrosh
, Ali A. Faruqi
, Janace Hart
, Shelly Roalstad
, Jennifer Graves
, Susan Lynch
, Emmanuelle Waubant
, Greg Aaen
, Anita Belman
, Leslie Benson
, Charlie Casper
, Tanuja Chitnis
, Mark Gorman
, Yolanda Harris
, Lauren Krupp
, Tim E. Lotze
, Sabina Lulu
, Jayne Ness
, Cody Olsen

Erik Roan, Moses Rodriguez, John Rose, Timothy C. Simmons, Jan Mendelt Tillema, Wendy Weber, Bianca Weinstock-Guttman

Neurology

University of British Columbia
University of California at San Francisco
University of Utah
Loma Linda University Health
Stony Brook University
Harvard University
Baylor College of Medicine
Mayo Clinic Rochester, MN

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Abstract

We explored the association between baseline gut microbiota (16S rRNA biomarker sequencing of stool samples) in 17 relapsing-remitting pediatric MS cases and risk of relapse over a mean 19.8 months follow-up. From the Kaplan-Meier curve, 25% relapsed within an estimated 166 days from baseline. A shorter time to relapse was associated with Fusobacteria depletion (p = 0.001 log-rank test), expansion of the Firmicutes (p = 0.003), and presence of the Archaea Euryarchaeota (p = 0.037). After covariate adjustments for age and immunomodulatory drug exposure, only absence (vs. presence) of Fusobacteria was associated with relapse risk (hazard ratio = 3.2 (95% CI: 1.2-9.0), p = 0.024). Further investigation is warranted. Findings could offer new targets to alter the MS disease course.

Original language	English
Pages (from-to)	153-157
Number of pages	5
Journal	Journal of the Neurological Sciences
Volume	363
DOIs	https://doi.org/10.1016/j.jns.2016.02.042
State	Published - Apr 15 2016

Keywords

16S rRNA
Cox regression
Gut microbiota
Kaplan-Meier
Pediatric multiple sclerosis
Relapse risk
Survival analyses

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10.1016/j.jns.2016.02.042

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Tremlett, H., Fadrosh, D. W., Faruqi, A. A., Hart, J., Roalstad, S., Graves, J., Lynch, S., Waubant, E., Aaen, G., Belman, A., Benson, L., Casper, C., Chitnis, T., Gorman, M., Harris, Y., Krupp, L., Lotze, T. E., Lulu, S., Ness, J., ... Weinstock-Guttman, B. (2016). Gut microbiota composition and relapse risk in pediatric MS: A pilot study. Journal of the Neurological Sciences, 363, 153-157. https://doi.org/10.1016/j.jns.2016.02.042

@article{1a48317b22bf419a83f0a2058b6e0aff,

title = "Gut microbiota composition and relapse risk in pediatric MS: A pilot study",

abstract = "We explored the association between baseline gut microbiota (16S rRNA biomarker sequencing of stool samples) in 17 relapsing-remitting pediatric MS cases and risk of relapse over a mean 19.8 months follow-up. From the Kaplan-Meier curve, 25\% relapsed within an estimated 166 days from baseline. A shorter time to relapse was associated with Fusobacteria depletion (p = 0.001 log-rank test), expansion of the Firmicutes (p = 0.003), and presence of the Archaea Euryarchaeota (p = 0.037). After covariate adjustments for age and immunomodulatory drug exposure, only absence (vs. presence) of Fusobacteria was associated with relapse risk (hazard ratio = 3.2 (95\% CI: 1.2-9.0), p = 0.024). Further investigation is warranted. Findings could offer new targets to alter the MS disease course.",

keywords = "16S rRNA, Cox regression, Gut microbiota, Kaplan-Meier, Pediatric multiple sclerosis, Relapse risk, Survival analyses",

author = "Helen Tremlett and Fadrosh, \{Douglas W.\} and Faruqi, \{Ali A.\} and Janace Hart and Shelly Roalstad and Jennifer Graves and Susan Lynch and Emmanuelle Waubant and Greg Aaen and Anita Belman and Leslie Benson and Charlie Casper and Tanuja Chitnis and Mark Gorman and Yolanda Harris and Lauren Krupp and Lotze, \{Tim E.\} and Sabina Lulu and Jayne Ness and Cody Olsen and Erik Roan and Moses Rodriguez and John Rose and Simmons, \{Timothy C.\} and Tillema, \{Jan Mendelt\} and Wendy Weber and Bianca Weinstock-Guttman",

year = "2016",

month = apr,

day = "15",

doi = "10.1016/j.jns.2016.02.042",

language = "English",

volume = "363",

pages = "153--157",

journal = "Journal of the Neurological Sciences",

issn = "0022-510X",

publisher = "Elsevier B.V.",

}

Tremlett, H, Fadrosh, DW, Faruqi, AA, Hart, J, Roalstad, S, Graves, J, Lynch, S, Waubant, E, Aaen, G, Belman, A, Benson, L, Casper, C, Chitnis, T, Gorman, M, Harris, Y, Krupp, L, Lotze, TE, Lulu, S, Ness, J, Olsen, C, Roan, E, Rodriguez, M, Rose, J, Simmons, TC, Tillema, JM, Weber, W & Weinstock-Guttman, B 2016, 'Gut microbiota composition and relapse risk in pediatric MS: A pilot study', Journal of the Neurological Sciences, vol. 363, pp. 153-157. https://doi.org/10.1016/j.jns.2016.02.042

TY - JOUR

T1 - Gut microbiota composition and relapse risk in pediatric MS

T2 - A pilot study

AU - Tremlett, Helen

AU - Fadrosh, Douglas W.

AU - Faruqi, Ali A.

AU - Hart, Janace

AU - Roalstad, Shelly

AU - Graves, Jennifer

AU - Lynch, Susan

AU - Waubant, Emmanuelle

AU - Aaen, Greg

AU - Belman, Anita

AU - Benson, Leslie

AU - Casper, Charlie

AU - Chitnis, Tanuja

AU - Gorman, Mark

AU - Harris, Yolanda

AU - Krupp, Lauren

AU - Lotze, Tim E.

AU - Lulu, Sabina

AU - Ness, Jayne

AU - Olsen, Cody

AU - Roan, Erik

AU - Rodriguez, Moses

AU - Rose, John

AU - Simmons, Timothy C.

AU - Tillema, Jan Mendelt

AU - Weber, Wendy

AU - Weinstock-Guttman, Bianca

PY - 2016/4/15

Y1 - 2016/4/15

N2 - We explored the association between baseline gut microbiota (16S rRNA biomarker sequencing of stool samples) in 17 relapsing-remitting pediatric MS cases and risk of relapse over a mean 19.8 months follow-up. From the Kaplan-Meier curve, 25% relapsed within an estimated 166 days from baseline. A shorter time to relapse was associated with Fusobacteria depletion (p = 0.001 log-rank test), expansion of the Firmicutes (p = 0.003), and presence of the Archaea Euryarchaeota (p = 0.037). After covariate adjustments for age and immunomodulatory drug exposure, only absence (vs. presence) of Fusobacteria was associated with relapse risk (hazard ratio = 3.2 (95% CI: 1.2-9.0), p = 0.024). Further investigation is warranted. Findings could offer new targets to alter the MS disease course.

AB - We explored the association between baseline gut microbiota (16S rRNA biomarker sequencing of stool samples) in 17 relapsing-remitting pediatric MS cases and risk of relapse over a mean 19.8 months follow-up. From the Kaplan-Meier curve, 25% relapsed within an estimated 166 days from baseline. A shorter time to relapse was associated with Fusobacteria depletion (p = 0.001 log-rank test), expansion of the Firmicutes (p = 0.003), and presence of the Archaea Euryarchaeota (p = 0.037). After covariate adjustments for age and immunomodulatory drug exposure, only absence (vs. presence) of Fusobacteria was associated with relapse risk (hazard ratio = 3.2 (95% CI: 1.2-9.0), p = 0.024). Further investigation is warranted. Findings could offer new targets to alter the MS disease course.

KW - 16S rRNA

KW - Cox regression

KW - Gut microbiota

KW - Kaplan-Meier

KW - Pediatric multiple sclerosis

KW - Relapse risk

KW - Survival analyses

UR - https://www.scopus.com/pages/publications/84959084455

U2 - 10.1016/j.jns.2016.02.042

DO - 10.1016/j.jns.2016.02.042

M3 - Article

C2 - 27000242

AN - SCOPUS:84959084455

SN - 0022-510X

VL - 363

SP - 153

EP - 157

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

ER -

Gut microbiota composition and relapse risk in pediatric MS: A pilot study

Abstract

Keywords

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