Growth inhibitory activity of a bis-benzimidazole-bridged arene ruthenium metalla-rectangle and -prism

Vaishali Vajpayee; Sun Mi Lee; Joeng Woo Park; Abhishek Dubey; Hyunuk Kim; Timothy R. Cook; Peter J. Stang; Ki Whan Chi

doi:10.1021/om301174s

Growth inhibitory activity of a bis-benzimidazole-bridged arene ruthenium metalla-rectangle and -prism

Vaishali Vajpayee
, Sun Mi Lee
, Joeng Woo Park
, Abhishek Dubey
, Hyunuk Kim
, Timothy R. Cook
, Peter J. Stang
, Ki Whan Chi

Chemistry

University of Ulsan
Korea Institute of Energy Research
University of Utah

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Two new supramolecular coordination complexes (SCCs) were obtained from the self-assembly of a new bis-benzimidazole bridged Ru acceptor, 4, with dipyridyl and tripyridyl donors, respectively. As part of a growing library of anticancer-active Ru-based SCCs, metalla-prism 6 selectively showed high cytotoxicities relative to cisplatin for a series of cancer cell lines, with IC₅₀ values as low as 8.41 μM for MCF7 cells, as determined from MTS assays.

Original language	English
Pages (from-to)	1563-1566
Number of pages	4
Journal	Organometallics
Volume	32
Issue number	6
DOIs	https://doi.org/10.1021/om301174s
State	Published - Mar 25 2013

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title = "Growth inhibitory activity of a bis-benzimidazole-bridged arene ruthenium metalla-rectangle and -prism",

abstract = "Two new supramolecular coordination complexes (SCCs) were obtained from the self-assembly of a new bis-benzimidazole bridged Ru acceptor, 4, with dipyridyl and tripyridyl donors, respectively. As part of a growing library of anticancer-active Ru-based SCCs, metalla-prism 6 selectively showed high cytotoxicities relative to cisplatin for a series of cancer cell lines, with IC50 values as low as 8.41 μM for MCF7 cells, as determined from MTS assays.",

author = "Vaishali Vajpayee and Lee, \{Sun Mi\} and Park, \{Joeng Woo\} and Abhishek Dubey and Hyunuk Kim and Cook, \{Timothy R.\} and Stang, \{Peter J.\} and Chi, \{Ki Whan\}",

year = "2013",

month = mar,

day = "25",

doi = "10.1021/om301174s",

language = "English",

volume = "32",

pages = "1563--1566",

journal = "Organometallics",

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T1 - Growth inhibitory activity of a bis-benzimidazole-bridged arene ruthenium metalla-rectangle and -prism

AU - Vajpayee, Vaishali

AU - Lee, Sun Mi

AU - Park, Joeng Woo

AU - Dubey, Abhishek

AU - Kim, Hyunuk

AU - Cook, Timothy R.

AU - Stang, Peter J.

AU - Chi, Ki Whan

PY - 2013/3/25

Y1 - 2013/3/25

N2 - Two new supramolecular coordination complexes (SCCs) were obtained from the self-assembly of a new bis-benzimidazole bridged Ru acceptor, 4, with dipyridyl and tripyridyl donors, respectively. As part of a growing library of anticancer-active Ru-based SCCs, metalla-prism 6 selectively showed high cytotoxicities relative to cisplatin for a series of cancer cell lines, with IC50 values as low as 8.41 μM for MCF7 cells, as determined from MTS assays.

AB - Two new supramolecular coordination complexes (SCCs) were obtained from the self-assembly of a new bis-benzimidazole bridged Ru acceptor, 4, with dipyridyl and tripyridyl donors, respectively. As part of a growing library of anticancer-active Ru-based SCCs, metalla-prism 6 selectively showed high cytotoxicities relative to cisplatin for a series of cancer cell lines, with IC50 values as low as 8.41 μM for MCF7 cells, as determined from MTS assays.

UR - https://www.scopus.com/pages/publications/84875412550

U2 - 10.1021/om301174s

DO - 10.1021/om301174s

M3 - Article

AN - SCOPUS:84875412550

SN - 0276-7333

VL - 32

SP - 1563

EP - 1566

JO - Organometallics

JF - Organometallics

IS - 6

ER -

Growth inhibitory activity of a bis-benzimidazole-bridged arene ruthenium metalla-rectangle and -prism

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