Gray matter correlations of cognition in incident Parkinson's disease

Turi O. Dalaker; Robert Zivadinov; Jan P. Larsen; Mona K. Beyer; Jennifer L. Cox; Guido Alves; Kolbjorn Bronnick; Ole Bjorn Tysnes; Ronald Antulov; Michael G. Dwyer; Dag Aarsland

doi:10.1002/mds.22867

Gray matter correlations of cognition in incident Parkinson's disease

Turi O. Dalaker
, Robert Zivadinov
, Jan P. Larsen
, Mona K. Beyer
, Jennifer L. Cox
, Guido Alves
, Kolbjorn Bronnick
, Ole Bjorn Tysnes
, Ronald Antulov
, Michael G. Dwyer
, Dag Aarsland

Neurology

SUNY Buffalo
Stavanger University Hospital
University of Bergen
University Hospital Centre Rijeka

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region-specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel-based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD.

Original language	English
Pages (from-to)	629-633
Number of pages	5
Journal	Movement Disorders
Volume	25
Issue number	5
DOIs	https://doi.org/10.1002/mds.22867
State	Published - Apr 15 2010

Keywords

Brain atrophy
Mild cognitive impairment
Mri
Parkinson's disease
Voxel-based morphometry

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10.1002/mds.22867

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title = "Gray matter correlations of cognition in incident Parkinson's disease",

abstract = "We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region-specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel-based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD.",

keywords = "Brain atrophy, Mild cognitive impairment, Mri, Parkinson's disease, Voxel-based morphometry",

author = "Dalaker, \{Turi O.\} and Robert Zivadinov and Larsen, \{Jan P.\} and Beyer, \{Mona K.\} and Cox, \{Jennifer L.\} and Guido Alves and Kolbjorn Bronnick and Tysnes, \{Ole Bjorn\} and Ronald Antulov and Dwyer, \{Michael G.\} and Dag Aarsland",

year = "2010",

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T1 - Gray matter correlations of cognition in incident Parkinson's disease

AU - Dalaker, Turi O.

AU - Zivadinov, Robert

AU - Larsen, Jan P.

AU - Beyer, Mona K.

AU - Cox, Jennifer L.

AU - Alves, Guido

AU - Bronnick, Kolbjorn

AU - Tysnes, Ole Bjorn

AU - Antulov, Ronald

AU - Dwyer, Michael G.

AU - Aarsland, Dag

PY - 2010/4/15

Y1 - 2010/4/15

N2 - We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region-specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel-based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD.

AB - We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region-specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel-based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD.

KW - Brain atrophy

KW - Mild cognitive impairment

KW - Mri

KW - Parkinson's disease

KW - Voxel-based morphometry

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EP - 633

JO - Movement Disorders

JF - Movement Disorders

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ER -

Gray matter correlations of cognition in incident Parkinson's disease

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Keywords

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