GRADE-Leitlinien: 2. Formulierung der Fragestellung und Entscheidung über wichtige Endpunkte

Gero Langer; Joerg J. Meerpohl; Matthias Perleth; Gerald Gartlehner; Angela Kaminski-Hartenthaler; Holger Schünemann

doi:10.1016/j.zefq.2012.05.018

GRADE-Leitlinien: 2. Formulierung der Fragestellung und Entscheidung über wichtige Endpunkte

Translated title of the contribution: GRADE Guidelines: 2. Framing the question and deciding on important outcomes

Gero Langer
, Joerg J. Meerpohl
, Matthias Perleth
, Gerald Gartlehner
, Angela Kaminski-Hartenthaler
, Holger Schünemann

Department of Epidemiology and Environmental Health

Martin Luther University Halle-Wittenberg
Universitätsklinikum Freiburgund
University of Freiburg
Abteilung Fachberatung Medizin
University for Continuing Education Krems

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

GRADE requires a clear specification of the relevant setting, population, intervention, and comparator. It also requires specification of all important outcomes - whether evidence from research studies is, or is not, available. For a particular management question, the population, intervention, and outcome should be sufficiently similar across studies so that a similar magnitude of effect is plausible. Guideline developers should specify the relative importance of the outcomes before gathering the evidence and again when evidence summaries are complete. In considering the importance of a surrogate outcome, authors should rate the importance of the patient-important outcome for which the surrogate is a substitute and subsequently rate down the quality of evidence for indirectness of outcome.

Translated title of the contribution	GRADE Guidelines: 2. Framing the question and deciding on important outcomes
Original language	German
Pages (from-to)	369-376
Number of pages	8
Journal	Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen
Volume	106
Issue number	5
DOIs	https://doi.org/10.1016/j.zefq.2012.05.018
State	Published - 2012

Keywords

GRADE
guideline development
indirectness
patient-important outcomes
PICO
quality of evidence
surrogate

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10.1016/j.zefq.2012.05.018

Cite this

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GRADE-Leitlinien: 2. Formulierung der Fragestellung und Entscheidung über wichtige Endpunkte

Abstract

Keywords

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