Grade Leitlinien: 15. Von der Evidenz zur Empfehlung - Determinanten, die Richtung und Stärke einer Empfehlung bestimmen

Barbara Nußbaumer; Gerald Gartlehner; Christina Kien; Angela Kaminski-Hartenthaler; Gero Langer; Joerg J. Meerpohl; Holger J. Schünemann

doi:10.1016/j.zefq.2014.08.004

Grade Leitlinien: 15. Von der Evidenz zur Empfehlung - Determinanten, die Richtung und Stärke einer Empfehlung bestimmen

Translated title of the contribution: GRADE guidelines 15: Going from evidence to recommendation - Determinants of a recommendation's direction and strength

Barbara Nußbaumer
, Gerald Gartlehner
, Christina Kien
, Angela Kaminski-Hartenthaler
, Gero Langer
, Joerg J. Meerpohl
, Holger J. Schünemann

Department of Epidemiology and Environmental Health

University for Continuing Education Krems
Martin Luther University Halle-Wittenberg
University of Freiburg

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

In the GRADE approach, the strength of a recommendation reflects the extent to which we can be confident that the composite desirable effects of a management strategy outweigh the composite undesirable effects. This article addresses GRADE's approach to determining the direction and strength of a recommendation. The GRADE describes the balance of desirable and undesirable outcomes of interest among alternative management strategies depending on four domains, namely estimates of effect for desirable and undesirable outcomes of interest, confidence in the estimates of effect, estimates of values and preferences, and resource use. Ultimately, guideline panels must use judgment in integrating these factors to make a strong or weak recommendation for or against an intervention.

Translated title of the contribution	GRADE guidelines 15: Going from evidence to recommendation - Determinants of a recommendation's direction and strength
Original language	German
Pages (from-to)	421-431
Number of pages	11
Journal	Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen
Volume	108
Issue number	7
DOIs	https://doi.org/10.1016/j.zefq.2014.08.004
State	Published - 2014

Keywords

evidence
GRADE
guideline development
quality of evidence
recommendation
strength of evidence

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Nußbaumer, B., Gartlehner, G., Kien, C., Kaminski-Hartenthaler, A., Langer, G., Meerpohl, J. J., & Schünemann, H. J. (2014). Grade Leitlinien: 15. Von der Evidenz zur Empfehlung - Determinanten, die Richtung und Stärke einer Empfehlung bestimmen. Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen, 108(7), 421-431. https://doi.org/10.1016/j.zefq.2014.08.004

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abstract = "In the GRADE approach, the strength of a recommendation reflects the extent to which we can be confident that the composite desirable effects of a management strategy outweigh the composite undesirable effects. This article addresses GRADE's approach to determining the direction and strength of a recommendation. The GRADE describes the balance of desirable and undesirable outcomes of interest among alternative management strategies depending on four domains, namely estimates of effect for desirable and undesirable outcomes of interest, confidence in the estimates of effect, estimates of values and preferences, and resource use. Ultimately, guideline panels must use judgment in integrating these factors to make a strong or weak recommendation for or against an intervention.",

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author = "Barbara Nu{\ss}baumer and Gerald Gartlehner and Christina Kien and Angela Kaminski-Hartenthaler and Gero Langer and Meerpohl, \{Joerg J.\} and Sch{\"u}nemann, \{Holger J.\}",

year = "2014",

doi = "10.1016/j.zefq.2014.08.004",

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Nußbaumer, B, Gartlehner, G, Kien, C, Kaminski-Hartenthaler, A, Langer, G, Meerpohl, JJ & Schünemann, HJ 2014, 'Grade Leitlinien: 15. Von der Evidenz zur Empfehlung - Determinanten, die Richtung und Stärke einer Empfehlung bestimmen', Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen, vol. 108, no. 7, pp. 421-431. https://doi.org/10.1016/j.zefq.2014.08.004

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T1 - Grade Leitlinien

T2 - 15. Von der Evidenz zur Empfehlung - Determinanten, die Richtung und Stärke einer Empfehlung bestimmen

AU - Nußbaumer, Barbara

AU - Gartlehner, Gerald

AU - Kien, Christina

AU - Kaminski-Hartenthaler, Angela

AU - Langer, Gero

AU - Meerpohl, Joerg J.

AU - Schünemann, Holger J.

PY - 2014

Y1 - 2014

N2 - In the GRADE approach, the strength of a recommendation reflects the extent to which we can be confident that the composite desirable effects of a management strategy outweigh the composite undesirable effects. This article addresses GRADE's approach to determining the direction and strength of a recommendation. The GRADE describes the balance of desirable and undesirable outcomes of interest among alternative management strategies depending on four domains, namely estimates of effect for desirable and undesirable outcomes of interest, confidence in the estimates of effect, estimates of values and preferences, and resource use. Ultimately, guideline panels must use judgment in integrating these factors to make a strong or weak recommendation for or against an intervention.

AB - In the GRADE approach, the strength of a recommendation reflects the extent to which we can be confident that the composite desirable effects of a management strategy outweigh the composite undesirable effects. This article addresses GRADE's approach to determining the direction and strength of a recommendation. The GRADE describes the balance of desirable and undesirable outcomes of interest among alternative management strategies depending on four domains, namely estimates of effect for desirable and undesirable outcomes of interest, confidence in the estimates of effect, estimates of values and preferences, and resource use. Ultimately, guideline panels must use judgment in integrating these factors to make a strong or weak recommendation for or against an intervention.

KW - evidence

KW - GRADE

KW - guideline development

KW - quality of evidence

KW - recommendation

KW - strength of evidence

UR - https://www.scopus.com/pages/publications/84940166492

U2 - 10.1016/j.zefq.2014.08.004

DO - 10.1016/j.zefq.2014.08.004

M3 - Article

C2 - 25444301

AN - SCOPUS:84940166492

SN - 1865-9217

VL - 108

SP - 421

EP - 431

JO - Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen

JF - Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen

IS - 7

ER -

Grade Leitlinien: 15. Von der Evidenz zur Empfehlung - Determinanten, die Richtung und Stärke einer Empfehlung bestimmen

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Keywords

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