Glycosaminoglucans alter the conformation of interferon-gamma

Vandana Balasubramanian; Murali Ramanathan

doi:10.1006/cyto.1999.0592

Glycosaminoglucans alter the conformation of interferon-gamma

Vandana Balasubramanian
, Murali Ramanathan

Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Interferon-γ (IFN-γ) is a potent immunomodulatory cytokine whose physiological roles are modulated by the extracellular matrix. Here, circular dichroism and fluorescence spectroscopic techniques are used to demonstrate that low molecular weight heparin and chondroitin sulfate cause significant changes in secondary and tertiary structure of IFN-γ. The results suggest that heparin and chondroitin sulfate modulate IFN-γ activity by causing structural changes in the IFN-γ dimer. (C) 2000 Academic Press.

Original language	English
Pages (from-to)	466-471
Number of pages	6
Journal	Cytokine
Volume	12
Issue number	5
DOIs	https://doi.org/10.1006/cyto.1999.0592
State	Published - May 2000

Keywords

Chondroitin sulfate
Circular dichroism
Extracellular matrix
Fluorescence spectroscopy
Heparin
IFN-gamma

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10.1006/cyto.1999.0592

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AB - Interferon-γ (IFN-γ) is a potent immunomodulatory cytokine whose physiological roles are modulated by the extracellular matrix. Here, circular dichroism and fluorescence spectroscopic techniques are used to demonstrate that low molecular weight heparin and chondroitin sulfate cause significant changes in secondary and tertiary structure of IFN-γ. The results suggest that heparin and chondroitin sulfate modulate IFN-γ activity by causing structural changes in the IFN-γ dimer. (C) 2000 Academic Press.

KW - Chondroitin sulfate

KW - Circular dichroism

KW - Extracellular matrix

KW - Fluorescence spectroscopy

KW - Heparin

KW - IFN-gamma

UR - https://www.scopus.com/pages/publications/0033625769

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ER -

Glycosaminoglucans alter the conformation of interferon-gamma

Abstract

Keywords

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