Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Brian M. Wolpin; Cosmeri Rizzato; Peter Kraft; Charles Kooperberg; Gloria M. Petersen; Zhaoming Wang; Alan A. Arslan; Laura Beane-Freeman; Paige M. Bracci; Julie Buring; Federico Canzian; Eric J. Duell; Steven Gallinger; Graham G. Giles; Gary E. Goodman; Phyllis J. Goodman; Eric J. Jacobs; Aruna Kamineni; Alison P. Klein; Laurence N. Kolonel; Matthew H. Kulke; Donghui Li; Núria Malats; Sara H. Olson; Harvey A. Risch; Howard D. Sesso; Kala Visvanathan; Emily White; Wei Zheng; Christian C. Abnet; Demetrius Albanes; Gabriella Andreotti; Melissa A. Austin; Richard Barfield; Daniela Basso; Sonja I. Berndt; Marie Christine Boutron-Ruault; Michelle Brotzman; Markus W. Büchler; H. Bas Bueno-De-Mesquita; Peter Bugert; Laurie Burdette; Daniele Campa; Neil E. Caporaso; Gabriele Capurso; Charles Chung; Michelle Cotterchio; Eithne Costello; Joanne Elena; Niccola Funel; J. Michael Gaziano; Nathalia A. Giese; Edward L. Giovannucci; Michael Goggins; Megan J. Gorman; Myron Gross; Christopher A. Haiman; Manal Hassan; Kathy J. Helzlsouer; Brian E. Henderson; Elizabeth A. Holly; Nan Hu; David J. Hunter; Federico Innocenti; Mazda Jenab; Rudolf Kaaks; Timothy J. Key; Kay Tee Khaw; Eric A. Klein; Manolis Kogevinas; Vittorio Krogh; Juozas Kupcinskas; Robert C. Kurtz; Andrea Lacroix; Maria T. Landi; Stefano Landi; Loic Le Marchand; Andrea Mambrini; Satu Mannisto; Roger L. Milne; Yusuke Nakamura; Ann L. Oberg; Kouros Owzar; Alpa V. Patel; Petra H.M. Peeters; Ulrike Peters; Raffaele Pezzilli; Ada Piepoli; Miquel Porta; Francisco X. Real; Elio Riboli; Nathaniel Rothman; Aldo Scarpa; Xiao Ou Shu; Debra T. Silverman; Pavel Soucek; Malin Sund; Renata Talar-Wojnarowska; Philip R. Taylor; George E. Theodoropoulos; Mark Thornquist; Anne Tjønneland; Geoffrey S. Tobias; Dimitrios Trichopoulos; Pavel Vodicka; Jean Wactawski-Wende; Nicolas Wentzensen; Chen Wu; Herbert Yu; Kai Yu; Anne Zeleniuch-Jacquotte; Robert Hoover; Patricia Hartge; Charles Fuchs; Stephen J. Chanock; Rachael S. Stolzenberg-Solomon; Laufey T. Amundadottir

doi:10.1038/ng.3052

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Brian M. Wolpin
, Cosmeri Rizzato
, Peter Kraft
, Charles Kooperberg
, Gloria M. Petersen
, Zhaoming Wang
, Alan A. Arslan
, Laura Beane-Freeman
, Paige M. Bracci
, Julie Buring
, Federico Canzian
, Eric J. Duell
, Steven Gallinger
, Graham G. Giles
, Gary E. Goodman
, Phyllis J. Goodman
, Eric J. Jacobs
, Aruna Kamineni
, Alison P. Klein
, Laurence N. Kolonel

Matthew H. Kulke, Donghui Li, Núria Malats, Sara H. Olson, Harvey A. Risch, Howard D. Sesso, Kala Visvanathan, Emily White, Wei Zheng, Christian C. Abnet, Demetrius Albanes, Gabriella Andreotti, Melissa A. Austin, Richard Barfield, Daniela Basso, Sonja I. Berndt, Marie Christine Boutron-Ruault, Michelle Brotzman, Markus W. Büchler, H. Bas Bueno-De-Mesquita, Peter Bugert, Laurie Burdette, Daniele Campa, Neil E. Caporaso, Gabriele Capurso, Charles Chung, Michelle Cotterchio, Eithne Costello, Joanne Elena, Niccola Funel, J. Michael Gaziano, Nathalia A. Giese, Edward L. Giovannucci, Michael Goggins, Megan J. Gorman, Myron Gross, Christopher A. Haiman, Manal Hassan, Kathy J. Helzlsouer, Brian E. Henderson, Elizabeth A. Holly, Nan Hu, David J. Hunter, Federico Innocenti, Mazda Jenab, Rudolf Kaaks, Timothy J. Key, Kay Tee Khaw, Eric A. Klein, Manolis Kogevinas, Vittorio Krogh, Juozas Kupcinskas, Robert C. Kurtz, Andrea Lacroix, Maria T. Landi, Stefano Landi, Loic Le Marchand, Andrea Mambrini, Satu Mannisto, Roger L. Milne, Yusuke Nakamura, Ann L. Oberg, Kouros Owzar, Alpa V. Patel, Petra H.M. Peeters, Ulrike Peters, Raffaele Pezzilli, Ada Piepoli, Miquel Porta, Francisco X. Real, Elio Riboli, Nathaniel Rothman, Aldo Scarpa, Xiao Ou Shu, Debra T. Silverman, Pavel Soucek, Malin Sund, Renata Talar-Wojnarowska, Philip R. Taylor, George E. Theodoropoulos, Mark Thornquist, Anne Tjønneland, Geoffrey S. Tobias, Dimitrios Trichopoulos, Pavel Vodicka, Jean Wactawski-Wende, Nicolas Wentzensen, Chen Wu, Herbert Yu, Kai Yu, Anne Zeleniuch-Jacquotte, Robert Hoover, Patricia Hartge, Charles Fuchs, Stephen J. Chanock, Rachael S. Stolzenberg-Solomon, Laufey T. Amundadottir

School of Public Health and Health Professions

Dana-Farber Cancer Institute
Brigham and Women’s Hospital
German Cancer Research Center
Harvard University
Fred Hutchinson Cancer Research Center
Mayo Clinic Rochester, MN
National Institutes of Health
New York University
University of California at San Francisco
Bellvitge Biomedical Research Institute
University of Toronto
Cancer Council Victoria
University of Melbourne
Monash University
Southwest Oncology Group Statistical Center
American Cancer Society
Group Health Cooperative
Johns Hopkins University
University of Hawai'i at Mānoa
University of Texas MD Anderson Cancer Center
Spanish National Cancer Research Centre (CNIO)
Memorial Sloan-Kettering Cancer Center
Yale University
SUNY Buffalo
University of Washington
Vanderbilt University
Azienda Ospedaliera di Padova
University Paris-Sud
Institut Gustave Roussy
Westat
Heidelberg University
National Institute of Public Health and the Environment
Utrecht University
University of Rome La Sapienza
National Institute for Health and Care Research
University and University Hospital of Pisa
VA Medical Center
University of Minnesota Twin Cities
University of Southern California
Mercy Medical Center Baltimore
University of North Carolina at Chapel Hill
International Agency for Research on Cancer
University of Oxford
University of Cambridge
Cleveland Clinic Foundation
(ISGlobal) Instituto de Salud Global de Barcelona
Hospital del Mar
University of West Attica
IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano
Lithuanian University of Health Sciences
University of Pisa
Oncology Department
National Institute for Health and Welfare
The University of Tokyo
Duke University
Imperial College London
Pancreas Unit, Department of Digestive Diseases and Internal Medicine, SantOrsola-Malpighi Hospital
IRCCS Ospedale Casa Sollievo della Sofferenza - San Giovanni Rotondo (FG)
Autonomous University of Barcelona
Centro de Investigación Biomédicaen Red de Epidemiología y Salud Pública (CIBERESP)
Pompeu Fabra University
ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona
Czech National Institute of Public Health
Umeå University
Medical University of Łódź
Hippokration General Hospital
Danish Cancer Society
Academy of Athens
Helenic Health Foundation
Czech Academy of Sciences

Research output: Contribution to journal › Article › peer-review

297 Scopus citations

Abstract

We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10^-12), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10^-10), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10^-9) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10^-8). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10^-14). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10^-7) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

Original language	English
Pages (from-to)	994-1000
Number of pages	7
Journal	Nature Genetics
Volume	46
Issue number	9
DOIs	https://doi.org/10.1038/ng.3052
State	Published - 2014

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Wolpin, B. M., Rizzato, C., Kraft, P., Kooperberg, C., Petersen, G. M., Wang, Z., Arslan, A. A., Beane-Freeman, L., Bracci, P. M., Buring, J., Canzian, F., Duell, E. J., Gallinger, S., Giles, G. G., Goodman, G. E., Goodman, P. J., Jacobs, E. J., Kamineni, A., Klein, A. P., ... Amundadottir, L. T. (2014). Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Nature Genetics, 46(9), 994-1000. https://doi.org/10.1038/ng.3052

@article{ec3894a218b741efb4457001ec3399bd,

title = "Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer",

abstract = "We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95\% confidence interval (CI) 0.74-0.84, P = 3.0 {\texttimes} 10-12), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95\% CI 1.30-1.65, P = 1.1 {\texttimes} 10-10), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95\% CI 1.10-1.20, P = 2.4 {\texttimes} 10-9) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95\% CI 1.12-1.25, P = 1.2 {\texttimes} 10-8). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95\% CI 0.76-0.85, P = 9.8 {\texttimes} 10-14). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 {\texttimes} 10-7) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.",

author = "Wolpin, \{Brian M.\} and Cosmeri Rizzato and Peter Kraft and Charles Kooperberg and Petersen, \{Gloria M.\} and Zhaoming Wang and Arslan, \{Alan A.\} and Laura Beane-Freeman and Bracci, \{Paige M.\} and Julie Buring and Federico Canzian and Duell, \{Eric J.\} and Steven Gallinger and Giles, \{Graham G.\} and Goodman, \{Gary E.\} and Goodman, \{Phyllis J.\} and Jacobs, \{Eric J.\} and Aruna Kamineni and Klein, \{Alison P.\} and Kolonel, \{Laurence N.\} and Kulke, \{Matthew H.\} and Donghui Li and N{\'u}ria Malats and Olson, \{Sara H.\} and Risch, \{Harvey A.\} and Sesso, \{Howard D.\} and Kala Visvanathan and Emily White and Wei Zheng and Abnet, \{Christian C.\} and Demetrius Albanes and Gabriella Andreotti and Austin, \{Melissa A.\} and Richard Barfield and Daniela Basso and Berndt, \{Sonja I.\} and Boutron-Ruault, \{Marie Christine\} and Michelle Brotzman and B{\"u}chler, \{Markus W.\} and Bueno-De-Mesquita, \{H. Bas\} and Peter Bugert and Laurie Burdette and Daniele Campa and Caporaso, \{Neil E.\} and Gabriele Capurso and Charles Chung and Michelle Cotterchio and Eithne Costello and Joanne Elena and Niccola Funel and Gaziano, \{J. Michael\} and Giese, \{Nathalia A.\} and Giovannucci, \{Edward L.\} and Michael Goggins and Gorman, \{Megan J.\} and Myron Gross and Haiman, \{Christopher A.\} and Manal Hassan and Helzlsouer, \{Kathy J.\} and Henderson, \{Brian E.\} and Holly, \{Elizabeth A.\} and Nan Hu and Hunter, \{David J.\} and Federico Innocenti and Mazda Jenab and Rudolf Kaaks and Key, \{Timothy J.\} and Khaw, \{Kay Tee\} and Klein, \{Eric A.\} and Manolis Kogevinas and Vittorio Krogh and Juozas Kupcinskas and Kurtz, \{Robert C.\} and Andrea Lacroix and Landi, \{Maria T.\} and Stefano Landi and \{Le Marchand\}, Loic and Andrea Mambrini and Satu Mannisto and Milne, \{Roger L.\} and Yusuke Nakamura and Oberg, \{Ann L.\} and Kouros Owzar and Patel, \{Alpa V.\} and Peeters, \{Petra H.M.\} and Ulrike Peters and Raffaele Pezzilli and Ada Piepoli and Miquel Porta and Real, \{Francisco X.\} and Elio Riboli and Nathaniel Rothman and Aldo Scarpa and Shu, \{Xiao Ou\} and Silverman, \{Debra T.\} and Pavel Soucek and Malin Sund and Renata Talar-Wojnarowska and Taylor, \{Philip R.\} and Theodoropoulos, \{George E.\} and Mark Thornquist and Anne Tj{\o}nneland and Tobias, \{Geoffrey S.\} and Dimitrios Trichopoulos and Pavel Vodicka and Jean Wactawski-Wende and Nicolas Wentzensen and Chen Wu and Herbert Yu and Kai Yu and Anne Zeleniuch-Jacquotte and Robert Hoover and Patricia Hartge and Charles Fuchs and Chanock, \{Stephen J.\} and Stolzenberg-Solomon, \{Rachael S.\} and Amundadottir, \{Laufey T.\}",

year = "2014",

doi = "10.1038/ng.3052",

language = "English",

volume = "46",

pages = "994--1000",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "9",

}

Wolpin, BM, Rizzato, C, Kraft, P, Kooperberg, C, Petersen, GM, Wang, Z, Arslan, AA, Beane-Freeman, L, Bracci, PM, Buring, J, Canzian, F, Duell, EJ, Gallinger, S, Giles, GG, Goodman, GE, Goodman, PJ, Jacobs, EJ, Kamineni, A, Klein, AP, Kolonel, LN, Kulke, MH, Li, D, Malats, N, Olson, SH, Risch, HA, Sesso, HD, Visvanathan, K, White, E, Zheng, W, Abnet, CC, Albanes, D, Andreotti, G, Austin, MA, Barfield, R, Basso, D, Berndt, SI, Boutron-Ruault, MC, Brotzman, M, Büchler, MW, Bueno-De-Mesquita, HB, Bugert, P, Burdette, L, Campa, D, Caporaso, NE, Capurso, G, Chung, C, Cotterchio, M, Costello, E, Elena, J, Funel, N, Gaziano, JM, Giese, NA, Giovannucci, EL, Goggins, M, Gorman, MJ, Gross, M, Haiman, CA, Hassan, M, Helzlsouer, KJ, Henderson, BE, Holly, EA, Hu, N, Hunter, DJ, Innocenti, F, Jenab, M, Kaaks, R, Key, TJ, Khaw, KT, Klein, EA, Kogevinas, M, Krogh, V, Kupcinskas, J, Kurtz, RC, Lacroix, A, Landi, MT, Landi, S, Le Marchand, L, Mambrini, A, Mannisto, S, Milne, RL, Nakamura, Y, Oberg, AL, Owzar, K, Patel, AV, Peeters, PHM, Peters, U, Pezzilli, R, Piepoli, A, Porta, M, Real, FX, Riboli, E, Rothman, N, Scarpa, A, Shu, XO, Silverman, DT, Soucek, P, Sund, M, Talar-Wojnarowska, R, Taylor, PR, Theodoropoulos, GE, Thornquist, M, Tjønneland, A, Tobias, GS, Trichopoulos, D, Vodicka, P, Wactawski-Wende, J, Wentzensen, N, Wu, C, Yu, H, Yu, K, Zeleniuch-Jacquotte, A, Hoover, R, Hartge, P, Fuchs, C, Chanock, SJ, Stolzenberg-Solomon, RS & Amundadottir, LT 2014, 'Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer', Nature Genetics, vol. 46, no. 9, pp. 994-1000. https://doi.org/10.1038/ng.3052

TY - JOUR

T1 - Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

AU - Wolpin, Brian M.

AU - Rizzato, Cosmeri

AU - Kraft, Peter

AU - Kooperberg, Charles

AU - Petersen, Gloria M.

AU - Wang, Zhaoming

AU - Arslan, Alan A.

AU - Beane-Freeman, Laura

AU - Bracci, Paige M.

AU - Buring, Julie

AU - Canzian, Federico

AU - Duell, Eric J.

AU - Gallinger, Steven

AU - Giles, Graham G.

AU - Goodman, Gary E.

AU - Goodman, Phyllis J.

AU - Jacobs, Eric J.

AU - Kamineni, Aruna

AU - Klein, Alison P.

AU - Kolonel, Laurence N.

AU - Kulke, Matthew H.

AU - Li, Donghui

AU - Malats, Núria

AU - Olson, Sara H.

AU - Risch, Harvey A.

AU - Sesso, Howard D.

AU - Visvanathan, Kala

AU - White, Emily

AU - Zheng, Wei

AU - Abnet, Christian C.

AU - Albanes, Demetrius

AU - Andreotti, Gabriella

AU - Austin, Melissa A.

AU - Barfield, Richard

AU - Basso, Daniela

AU - Berndt, Sonja I.

AU - Boutron-Ruault, Marie Christine

AU - Brotzman, Michelle

AU - Büchler, Markus W.

AU - Bueno-De-Mesquita, H. Bas

AU - Bugert, Peter

AU - Burdette, Laurie

AU - Campa, Daniele

AU - Caporaso, Neil E.

AU - Capurso, Gabriele

AU - Chung, Charles

AU - Cotterchio, Michelle

AU - Costello, Eithne

AU - Elena, Joanne

AU - Funel, Niccola

AU - Gaziano, J. Michael

AU - Giese, Nathalia A.

AU - Giovannucci, Edward L.

AU - Goggins, Michael

AU - Gorman, Megan J.

AU - Gross, Myron

AU - Haiman, Christopher A.

AU - Hassan, Manal

AU - Helzlsouer, Kathy J.

AU - Henderson, Brian E.

AU - Holly, Elizabeth A.

AU - Hu, Nan

AU - Hunter, David J.

AU - Innocenti, Federico

AU - Jenab, Mazda

AU - Kaaks, Rudolf

AU - Key, Timothy J.

AU - Khaw, Kay Tee

AU - Klein, Eric A.

AU - Kogevinas, Manolis

AU - Krogh, Vittorio

AU - Kupcinskas, Juozas

AU - Kurtz, Robert C.

AU - Lacroix, Andrea

AU - Landi, Maria T.

AU - Landi, Stefano

AU - Le Marchand, Loic

AU - Mambrini, Andrea

AU - Mannisto, Satu

AU - Milne, Roger L.

AU - Nakamura, Yusuke

AU - Oberg, Ann L.

AU - Owzar, Kouros

AU - Patel, Alpa V.

AU - Peeters, Petra H.M.

AU - Peters, Ulrike

AU - Pezzilli, Raffaele

AU - Piepoli, Ada

AU - Porta, Miquel

AU - Real, Francisco X.

AU - Riboli, Elio

AU - Rothman, Nathaniel

AU - Scarpa, Aldo

AU - Shu, Xiao Ou

AU - Silverman, Debra T.

AU - Soucek, Pavel

AU - Sund, Malin

AU - Talar-Wojnarowska, Renata

AU - Taylor, Philip R.

AU - Theodoropoulos, George E.

AU - Thornquist, Mark

AU - Tjønneland, Anne

AU - Tobias, Geoffrey S.

AU - Trichopoulos, Dimitrios

AU - Vodicka, Pavel

AU - Wactawski-Wende, Jean

AU - Wentzensen, Nicolas

AU - Wu, Chen

AU - Yu, Herbert

AU - Yu, Kai

AU - Zeleniuch-Jacquotte, Anne

AU - Hoover, Robert

AU - Hartge, Patricia

AU - Fuchs, Charles

AU - Chanock, Stephen J.

AU - Stolzenberg-Solomon, Rachael S.

AU - Amundadottir, Laufey T.

PY - 2014

Y1 - 2014

N2 - We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10-12), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10-10), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10-9) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10-8). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10-14). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10-7) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

AB - We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10-12), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10-10), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10-9) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10-8). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10-14). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10-7) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

UR - https://www.scopus.com/pages/publications/84938423709

U2 - 10.1038/ng.3052

DO - 10.1038/ng.3052

M3 - Article

C2 - 25086665

AN - SCOPUS:84938423709

SN - 1061-4036

VL - 46

SP - 994

EP - 1000

JO - Nature Genetics

JF - Nature Genetics

IS - 9

ER -

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

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