Genetic mapping of a new promoter for the lac operon

Jeremy Bruenn; Paula De Lucia-Curtin

doi:10.1016/0022-2836(75)90134-5

Genetic mapping of a new promoter for the lac operon

Jeremy Bruenn
, Paula De Lucia-Curtin

Biological Sciences

Cold Spring Harbor Laboratory

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A mutation (or group of mutations) necessary for the synthesis of increased quantities of lac mRNA has been localized within the structural gene for the lac repressor (lacI). This mutation is probably a new cyclic AMP-binding protein-dependent promoter within the I gene. We propose that the synthesis of lac mRNA in the mutant is initiated within the I gene, and that transcriptional initiation continues to occur normally at the wild-type I promoter.

Original language	English
Pages (from-to)	311-317
Number of pages	7
Journal	Journal of Molecular Biology
Volume	93
Issue number	2
DOIs	https://doi.org/10.1016/0022-2836(75)90134-5
State	Published - Apr 5 1975

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title = "Genetic mapping of a new promoter for the lac operon",

abstract = "A mutation (or group of mutations) necessary for the synthesis of increased quantities of lac mRNA has been localized within the structural gene for the lac repressor (lacI). This mutation is probably a new cyclic AMP-binding protein-dependent promoter within the I gene. We propose that the synthesis of lac mRNA in the mutant is initiated within the I gene, and that transcriptional initiation continues to occur normally at the wild-type I promoter.",

author = "Jeremy Bruenn and \{De Lucia-Curtin\}, Paula",

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AU - Bruenn, Jeremy

AU - De Lucia-Curtin, Paula

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Y1 - 1975/4/5

N2 - A mutation (or group of mutations) necessary for the synthesis of increased quantities of lac mRNA has been localized within the structural gene for the lac repressor (lacI). This mutation is probably a new cyclic AMP-binding protein-dependent promoter within the I gene. We propose that the synthesis of lac mRNA in the mutant is initiated within the I gene, and that transcriptional initiation continues to occur normally at the wild-type I promoter.

AB - A mutation (or group of mutations) necessary for the synthesis of increased quantities of lac mRNA has been localized within the structural gene for the lac repressor (lacI). This mutation is probably a new cyclic AMP-binding protein-dependent promoter within the I gene. We propose that the synthesis of lac mRNA in the mutant is initiated within the I gene, and that transcriptional initiation continues to occur normally at the wild-type I promoter.

UR - https://www.scopus.com/pages/publications/0016640143

U2 - 10.1016/0022-2836(75)90134-5

DO - 10.1016/0022-2836(75)90134-5

M3 - Article

C2 - 168389

AN - SCOPUS:0016640143

SN - 0022-2836

VL - 93

SP - 311

EP - 317

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

IS - 2

ER -

Genetic mapping of a new promoter for the lac operon

Abstract

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