TY - GEN
T1 - Generating hypothesis
T2 - 8th International Conference on Bioinformatics and Computational Biology, BICOB 2016
AU - Gopalakrishnan, Vishrawas
AU - Jha, Kishlay
AU - Zhang, Aidong
AU - Jin, Wei
N1 - Publisher Copyright:
Copyright ISCA.
PY - 2016
Y1 - 2016
N2 - Literature-based discovery, a method by which one estimates a plausible relationship between hitherto unconnected or unrelated terms is an important component of biomedical text mining. In this paper, we propose a new method which creates a graph-based knowledge base and formulates the problem as one of discovering and ranking paths in a graph. The proposed approach is contextually sensitive, while at the same time mindful of global characteristics. The proposed method, unlike many existing techniques, is not limited to immediate neighbor search, nor does it require any user intervention. At the same time it has the ability to discover meaningful and specific "bridge" terms with high precision. In some cases, it has also identified relationships well in advance when compared to popular publications investigating the corresponding discoveries.
AB - Literature-based discovery, a method by which one estimates a plausible relationship between hitherto unconnected or unrelated terms is an important component of biomedical text mining. In this paper, we propose a new method which creates a graph-based knowledge base and formulates the problem as one of discovering and ranking paths in a graph. The proposed approach is contextually sensitive, while at the same time mindful of global characteristics. The proposed method, unlike many existing techniques, is not limited to immediate neighbor search, nor does it require any user intervention. At the same time it has the ability to discover meaningful and specific "bridge" terms with high precision. In some cases, it has also identified relationships well in advance when compared to popular publications investigating the corresponding discoveries.
UR - https://www.scopus.com/pages/publications/84973667681
M3 - Conference contribution
AN - SCOPUS:84973667681
T3 - Proceedings of the 8th International Conference on Bioinformatics and Computational Biology, BICOB 2016
SP - 23
EP - 30
BT - Proceedings of the 8th International Conference on Bioinformatics and Computational Biology, BICOB 2016
A2 - Haspel, Nurit
A2 - Ioerger, Thomas
PB - The International Society for Computers and Their Applications (ISCA)
Y2 - 4 April 2016 through 6 April 2016
ER -