Further Studies on the Effect of ACTH on Cholesterol Side Chain Cleavage Cytochrome P-450 in Rat Adrenal Mitochondria

Alexander C. Brownie; Douglas P. Paul

doi:10.1080/07435807409088997

Further Studies on the Effect of ACTH on Cholesterol Side Chain Cleavage Cytochrome P-450 in Rat Adrenal Mitochondria

Alexander C. Brownie
, Douglas P. Paul

Biochemistry

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Mitochondria have been isolated from zona fasciculata-reticularis adrenal tissue of hypophysectomized rats following injection of ACTH or dibutyryl cyclic AMP. It has been possible to observe increased binding of cholesterol to a side chain cleavage cytochrome P-450 in such mitochondria by spectro-photometric techniques. These observations suggest an approach to the isolation of the “labile factor” involved in the mechanism of action of ACTH.

Original language	English
Pages (from-to)	321-330
Number of pages	10
Journal	Endocrine Research Communications
Volume	1
Issue number	3
DOIs	https://doi.org/10.1080/07435807409088997
State	Published - Jan 1 1974

Access to Document

10.1080/07435807409088997

Cite this

@article{3fde3409630d4691819830cd5e433b1b,

title = "Further Studies on the Effect of ACTH on Cholesterol Side Chain Cleavage Cytochrome P-450 in Rat Adrenal Mitochondria",

abstract = "Mitochondria have been isolated from zona fasciculata-reticularis adrenal tissue of hypophysectomized rats following injection of ACTH or dibutyryl cyclic AMP. It has been possible to observe increased binding of cholesterol to a side chain cleavage cytochrome P-450 in such mitochondria by spectro-photometric techniques. These observations suggest an approach to the isolation of the {\textquotedblleft}labile factor{\textquotedblright} involved in the mechanism of action of ACTH.",

author = "Brownie, \{Alexander C.\} and Paul, \{Douglas P.\}",

year = "1974",

month = jan,

day = "1",

doi = "10.1080/07435807409088997",

language = "English",

volume = "1",

pages = "321--330",

journal = "Endocrine Research Communications",

issn = "0093-6391",

publisher = "Marcel Dekker Inc.",

number = "3",

}

TY - JOUR

T1 - Further Studies on the Effect of ACTH on Cholesterol Side Chain Cleavage Cytochrome P-450 in Rat Adrenal Mitochondria

AU - Brownie, Alexander C.

AU - Paul, Douglas P.

PY - 1974/1/1

Y1 - 1974/1/1

N2 - Mitochondria have been isolated from zona fasciculata-reticularis adrenal tissue of hypophysectomized rats following injection of ACTH or dibutyryl cyclic AMP. It has been possible to observe increased binding of cholesterol to a side chain cleavage cytochrome P-450 in such mitochondria by spectro-photometric techniques. These observations suggest an approach to the isolation of the “labile factor” involved in the mechanism of action of ACTH.

AB - Mitochondria have been isolated from zona fasciculata-reticularis adrenal tissue of hypophysectomized rats following injection of ACTH or dibutyryl cyclic AMP. It has been possible to observe increased binding of cholesterol to a side chain cleavage cytochrome P-450 in such mitochondria by spectro-photometric techniques. These observations suggest an approach to the isolation of the “labile factor” involved in the mechanism of action of ACTH.

UR - https://www.scopus.com/pages/publications/0016303452

U2 - 10.1080/07435807409088997

DO - 10.1080/07435807409088997

M3 - Article

AN - SCOPUS:0016303452

SN - 0093-6391

VL - 1

SP - 321

EP - 330

JO - Endocrine Research Communications

JF - Endocrine Research Communications

IS - 3

ER -

Further Studies on the Effect of ACTH on Cholesterol Side Chain Cleavage Cytochrome P-450 in Rat Adrenal Mitochondria

Abstract

Access to Document

Other files and links

Fingerprint

Cite this