Abstract
The pathogenetic mechanism of many hearing disorders have not been fully defined. Studies of certain hearing disorders in man have suggested a role for the major histocompatibility complex (MHC)-encoded genes in disease pathogenesis. In a cohort of unrelated patients with Meniere's Disease, otosclerosis and strial presbycusis as well as other types of sensorineural hearing losses, we have identified an extended MHC haplotype common to the majority of these patients, supporting a hypothesis that a gene(s) within the MHC domain may confer susceptibility to these hearing ailments. In addition, a preliminary study of 27 individuals with various hearing maladies, a striking finding is that 44% of the patients express the following extended MHC haplotype in contrast to only 7% of the general population: DQw2-DR3-C4BSf-C4A0-G11:15-Bf:0.4-C2a-HSP70:7.5-TNFa5-B8-Cw7-A1. The expression of this haplotype by subsets of patients with hearing loss is significant in comparison to regional and international controls.
| Original language | English |
|---|---|
| Pages (from-to) | 666-671 |
| Number of pages | 6 |
| Journal | Acta Oto-Laryngologica |
| Volume | 116 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1996 |
Keywords
- Major histocompatibility complex genes
- Meniere's disease
- Otosclerosis
- Sensorineural hearing disorders
- Strial presbycusis
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