Further investigations of the serotonergic properties of the ibogaine- induced discriminative stimulus

Scott Helsley; Richard A. Rabin; Jerrold C. Winter

doi:10.1016/S0278-5846(98)00101-8

Further investigations of the serotonergic properties of the ibogaine- induced discriminative stimulus

Scott Helsley
, Richard A. Rabin
, Jerrold C. Winter

Pharmacology and Toxicology

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

1. 5-HT₃, 5-HT(2C), and 5-HT(1A) receptor ligands were assessed in rats trained to discriminate ibogaine from water. 2. Significant ibogaine- appropriate responding was observed following treatment with the 5-HT(2C) agonists MK-212 (79.6%) and mCPP (76.4%). This substitution was completely antagonized by metergoline, an agent with 5-HT(2C) antagonist properties. However, metergoline was ineffective against ibogaine itself. This suggests that although ibogaine may act as an agonist at 5-HT(2C) receptors, this interaction is not essential to its discriminative cue. 3. Neither the 5- HT₃ agonist, mCPBG (44.3%), nor the 5-HT₃ antagonist, ondansetron (48.9%) substituted for ibogaine. Likewise, the 5-HT(1A) agonist 8-OH-DPAT (34.7%) and the 5-HT(1A) antagonist WAY-100635 (30.1%) failed to substitute. Furthermore, WAY-100635 failed to antagonize the ibogaine cue. 4. Unlike 5- HT(2C) receptors, 5-HT(1A) and 5-HT₃ receptors do not appear to be involved in the ibogaine stimulus.

Original language	English
Pages (from-to)	317-326
Number of pages	10
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/S0278-5846(98)00101-8
State	Published - Feb 1999

Keywords

Drug discrimination
Hallucinogens
Ibogaine
Serotonin receptors

Access to Document

10.1016/S0278-5846(98)00101-8

Cite this

@article{88ab193a0e564b75989cfcb73ef163f5,

title = "Further investigations of the serotonergic properties of the ibogaine- induced discriminative stimulus",

abstract = "1. 5-HT3, 5-HT(2C), and 5-HT(1A) receptor ligands were assessed in rats trained to discriminate ibogaine from water. 2. Significant ibogaine- appropriate responding was observed following treatment with the 5-HT(2C) agonists MK-212 (79.6\%) and mCPP (76.4\%). This substitution was completely antagonized by metergoline, an agent with 5-HT(2C) antagonist properties. However, metergoline was ineffective against ibogaine itself. This suggests that although ibogaine may act as an agonist at 5-HT(2C) receptors, this interaction is not essential to its discriminative cue. 3. Neither the 5- HT3 agonist, mCPBG (44.3\%), nor the 5-HT3 antagonist, ondansetron (48.9\%) substituted for ibogaine. Likewise, the 5-HT(1A) agonist 8-OH-DPAT (34.7\%) and the 5-HT(1A) antagonist WAY-100635 (30.1\%) failed to substitute. Furthermore, WAY-100635 failed to antagonize the ibogaine cue. 4. Unlike 5- HT(2C) receptors, 5-HT(1A) and 5-HT3 receptors do not appear to be involved in the ibogaine stimulus.",

keywords = "Drug discrimination, Hallucinogens, Ibogaine, Serotonin receptors",

author = "Scott Helsley and Rabin, \{Richard A.\} and Winter, \{Jerrold C.\}",

year = "1999",

month = feb,

doi = "10.1016/S0278-5846(98)00101-8",

language = "English",

volume = "23",

pages = "317--326",

journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",

issn = "0278-5846",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Further investigations of the serotonergic properties of the ibogaine- induced discriminative stimulus

AU - Helsley, Scott

AU - Rabin, Richard A.

AU - Winter, Jerrold C.

PY - 1999/2

Y1 - 1999/2

N2 - 1. 5-HT3, 5-HT(2C), and 5-HT(1A) receptor ligands were assessed in rats trained to discriminate ibogaine from water. 2. Significant ibogaine- appropriate responding was observed following treatment with the 5-HT(2C) agonists MK-212 (79.6%) and mCPP (76.4%). This substitution was completely antagonized by metergoline, an agent with 5-HT(2C) antagonist properties. However, metergoline was ineffective against ibogaine itself. This suggests that although ibogaine may act as an agonist at 5-HT(2C) receptors, this interaction is not essential to its discriminative cue. 3. Neither the 5- HT3 agonist, mCPBG (44.3%), nor the 5-HT3 antagonist, ondansetron (48.9%) substituted for ibogaine. Likewise, the 5-HT(1A) agonist 8-OH-DPAT (34.7%) and the 5-HT(1A) antagonist WAY-100635 (30.1%) failed to substitute. Furthermore, WAY-100635 failed to antagonize the ibogaine cue. 4. Unlike 5- HT(2C) receptors, 5-HT(1A) and 5-HT3 receptors do not appear to be involved in the ibogaine stimulus.

AB - 1. 5-HT3, 5-HT(2C), and 5-HT(1A) receptor ligands were assessed in rats trained to discriminate ibogaine from water. 2. Significant ibogaine- appropriate responding was observed following treatment with the 5-HT(2C) agonists MK-212 (79.6%) and mCPP (76.4%). This substitution was completely antagonized by metergoline, an agent with 5-HT(2C) antagonist properties. However, metergoline was ineffective against ibogaine itself. This suggests that although ibogaine may act as an agonist at 5-HT(2C) receptors, this interaction is not essential to its discriminative cue. 3. Neither the 5- HT3 agonist, mCPBG (44.3%), nor the 5-HT3 antagonist, ondansetron (48.9%) substituted for ibogaine. Likewise, the 5-HT(1A) agonist 8-OH-DPAT (34.7%) and the 5-HT(1A) antagonist WAY-100635 (30.1%) failed to substitute. Furthermore, WAY-100635 failed to antagonize the ibogaine cue. 4. Unlike 5- HT(2C) receptors, 5-HT(1A) and 5-HT3 receptors do not appear to be involved in the ibogaine stimulus.

KW - Drug discrimination

KW - Hallucinogens

KW - Ibogaine

KW - Serotonin receptors

UR - https://www.scopus.com/pages/publications/0033081349

U2 - 10.1016/S0278-5846(98)00101-8

DO - 10.1016/S0278-5846(98)00101-8

M3 - Article

C2 - 10368872

AN - SCOPUS:0033081349

SN - 0278-5846

VL - 23

SP - 317

EP - 326

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

IS - 2

ER -

Further investigations of the serotonergic properties of the ibogaine- induced discriminative stimulus

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this