Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva

Marie Saitou; Eliza A. Gaylord; Erica Xu; Alison J. May; Lubov Neznanova; Sara Nathan; Anissa Grawe; Jolie Chang; William Ryan; Stefan Ruhl; Sarah M. Knox; Omer Gokcumen

doi:10.1016/j.celrep.2020.108402

Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva

Marie Saitou
, Eliza A. Gaylord
, Erica Xu
, Alison J. May
, Lubov Neznanova
, Sara Nathan
, Anissa Grawe
, Jolie Chang
, William Ryan
, Stefan Ruhl
, Sarah M. Knox
, Omer Gokcumen

SUNY Buffalo
The University of Chicago
Norwegian University of Life Sciences
University of California at San Francisco

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Saitou et al. present a detailed analysis of transcriptome variation among human fetal and adult salivary glands. Their analysis reveals specific developmental and regulatory processes, as well as cell-line heterogeneity, that shape the gland-specific functional variation.

Original language	English
Article number	108402
Journal	Cell Reports
Volume	33
Issue number	7
DOIs	https://doi.org/10.1016/j.celrep.2020.108402
State	Published - Nov 17 2020

Keywords

cell-line heterogeneity
developmental regulation
gene regulation
glycosylation
lincRNAs
regulatory architecture
salivary biomarkers
salivary mucins
salivary proteins
transcriptome

Access to Document

10.1016/j.celrep.2020.108402

Cite this

@article{b63bb933e4c946e68bbe614e7a8d866c,

title = "Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva",

abstract = "Saitou et al. present a detailed analysis of transcriptome variation among human fetal and adult salivary glands. Their analysis reveals specific developmental and regulatory processes, as well as cell-line heterogeneity, that shape the gland-specific functional variation.",

keywords = "cell-line heterogeneity, developmental regulation, gene regulation, glycosylation, lincRNAs, regulatory architecture, salivary biomarkers, salivary mucins, salivary proteins, transcriptome",

author = "Marie Saitou and Gaylord, \{Eliza A.\} and Erica Xu and May, \{Alison J.\} and Lubov Neznanova and Sara Nathan and Anissa Grawe and Jolie Chang and William Ryan and Stefan Ruhl and Knox, \{Sarah M.\} and Omer Gokcumen",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = nov,

day = "17",

doi = "10.1016/j.celrep.2020.108402",

language = "English",

volume = "33",

journal = "Cell Reports",

issn = "2639-1856",

publisher = "Elsevier B.V.",

number = "7",

}

TY - JOUR

T1 - Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva

AU - Saitou, Marie

AU - Gaylord, Eliza A.

AU - Xu, Erica

AU - May, Alison J.

AU - Neznanova, Lubov

AU - Nathan, Sara

AU - Grawe, Anissa

AU - Chang, Jolie

AU - Ryan, William

AU - Ruhl, Stefan

AU - Knox, Sarah M.

AU - Gokcumen, Omer

PY - 2020/11/17

Y1 - 2020/11/17

N2 - Saitou et al. present a detailed analysis of transcriptome variation among human fetal and adult salivary glands. Their analysis reveals specific developmental and regulatory processes, as well as cell-line heterogeneity, that shape the gland-specific functional variation.

AB - Saitou et al. present a detailed analysis of transcriptome variation among human fetal and adult salivary glands. Their analysis reveals specific developmental and regulatory processes, as well as cell-line heterogeneity, that shape the gland-specific functional variation.

KW - cell-line heterogeneity

KW - developmental regulation

KW - gene regulation

KW - glycosylation

KW - lincRNAs

KW - regulatory architecture

KW - salivary biomarkers

KW - salivary mucins

KW - salivary proteins

KW - transcriptome

UR - https://www.scopus.com/pages/publications/85096406998

U2 - 10.1016/j.celrep.2020.108402

DO - 10.1016/j.celrep.2020.108402

M3 - Article

C2 - 33207190

AN - SCOPUS:85096406998

SN - 2639-1856

VL - 33

JO - Cell Reports

JF - Cell Reports

IS - 7

M1 - 108402

ER -

Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this