@inproceedings{ffb25c80335545e8b8f8ce57ab045a18,
title = "Functional polylactide-based systems for delivery of cancer therapeutics",
abstract = "A series of studies are performed to develop functional polylactides (PLAs) and investigate their applications in anticancer therapeutic delivery. The synthetic approaches for a broad variety of functional PLAs are established. Several types of functional PLA-based drug delivery systems, including brush-like polymer-drug conjugates (PDCs), PDC-based nanoparticles and zwitterionic PDCs, have been prepared, and in vitro results suggest that they may potentially serve as potent anticancer nanotherapeutics. Novel cationic PLAs (CPLAs) have been synthesized, and their application as transfection agents in the delivery of anticancer small interfering RNA (siRNA) has been demonstrated. Unique CPLA-based nanocapsules enabling drug delivery, gene delivery, and drug-gene codelivery have also been achieved. These nanocapsules can effectively evade drug resistance of cancer cells. Synergistic treatment effects are observed in the drug-gene co-delivery via the nanocapsules.",
keywords = "Cancer, Drug delivery, Drug-gene co-delivery, Gene delivery, Polylactides",
author = "C. Cheng and H. Sun and Y. Yu and Chen, \{C. K.\} and J. Zou",
note = "Publisher Copyright: {\textcopyright} 2018 OOSV. All rights reserved.; 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference ; Conference date: 13-05-2018 Through 16-05-2018",
year = "2018",
language = "English",
series = "TechConnect Briefs 2018 - Advanced Materials",
publisher = "TechConnect",
pages = "93--96",
editor = "Bart Romanowicz and Fiona Case and Fiona Case and Matthew Laudon",
booktitle = "TechConnect Briefs 2018 - Biotech, Biomaterials and Biomedical",
}