TY - JOUR
T1 - Fruits and vegetables intake and gastric cancer risk
T2 - A pooled analysis within the Stomach cancer Pooling Project
AU - Ferro, Ana
AU - Costa, Ana Rute
AU - Morais, Samantha
AU - Bertuccio, Paola
AU - Rota, Matteo
AU - Pelucchi, Claudio
AU - Hu, Jinfu
AU - Johnson, Kenneth C.
AU - Zhang, Zuo Feng
AU - Palli, Domenico
AU - Ferraroni, Monica
AU - Yu, Guo Pei
AU - Bonzi, Rossella
AU - Peleteiro, Bárbara
AU - López-Carrillo, Lizbeth
AU - Tsugane, Shoichiro
AU - Hamada, Gerson Shigueaki
AU - Hidaka, Akihisa
AU - Malekzadeh, Reza
AU - Zaridze, David
AU - Maximovich, Dmitry
AU - Vioque, Jesus
AU - Navarrete-Muñoz, Eva M.
AU - Alguacil, Juan
AU - Castaño-Vinyals, Gemma
AU - Wolk, Alicja
AU - Håkansson, Niclas
AU - Hernández-Ramírez, Raúl Ulises
AU - Pakseresht, Mohammadreza
AU - Ward, Mary H.
AU - Pourfarzi, Farhad
AU - Mu, Lina
AU - López-Cervantes, Malaquias
AU - Persiani, Roberto
AU - Kurtz, Robert C.
AU - Lagiou, Areti
AU - Lagiou, Pagona
AU - Boffetta, Paolo
AU - Boccia, Stefania
AU - Negri, Eva
AU - Camargo, Maria Constanza
AU - Curado, Maria Paula
AU - La Vecchia, Carlo
AU - Lunet, Nuno
N1 - Publisher Copyright:
© 2020 UICC
PY - 2020/12/1
Y1 - 2020/12/1
N2 - A low intake of fruits and vegetables is a risk factor for gastric cancer, although there is uncertainty regarding the magnitude of the associations. In our study, the relationship between fruits and vegetables intake and gastric cancer was assessed, complementing a previous work on the association betweenconsumption of citrus fruits and gastric cancer. Data from 25 studies (8456 cases and 21 133 controls) with information on fruits and/or vegetables intake were used. A two-stage approach based on random-effects models was used to pool study-specific adjusted (sex, age and the main known risk factors for gastric cancer) odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Exposure-response relations, including linear and nonlinear associations, were modeled using one- and two-order fractional polynomials. Gastric cancer risk was lower for a higher intake of fruits (OR: 0.76, 95% CI: 0.64-0.90), noncitrus fruits (OR: 0.86, 95% CI: 0.73-1.02), vegetables (OR: 0.68, 95% CI: 0.56-0.84), and fruits and vegetables (OR: 0.61, 95% CI: 0.49-0.75); results were consistent across sociodemographic and lifestyles categories, as well as study characteristics. Exposure-response analyses showed an increasingly protective effect of portions/day of fruits (OR: 0.64, 95% CI: 0.57-0.73 for six portions), noncitrus fruits (OR: 0.71, 95% CI: 0.61-0.83 for six portions) and vegetables (OR: 0.51, 95% CI: 0.43-0.60 for 10 portions). A protective effect of all fruits, noncitrus fruits and vegetables was confirmed, supporting further dietary recommendations to decrease the burden of gastric cancer.
AB - A low intake of fruits and vegetables is a risk factor for gastric cancer, although there is uncertainty regarding the magnitude of the associations. In our study, the relationship between fruits and vegetables intake and gastric cancer was assessed, complementing a previous work on the association betweenconsumption of citrus fruits and gastric cancer. Data from 25 studies (8456 cases and 21 133 controls) with information on fruits and/or vegetables intake were used. A two-stage approach based on random-effects models was used to pool study-specific adjusted (sex, age and the main known risk factors for gastric cancer) odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Exposure-response relations, including linear and nonlinear associations, were modeled using one- and two-order fractional polynomials. Gastric cancer risk was lower for a higher intake of fruits (OR: 0.76, 95% CI: 0.64-0.90), noncitrus fruits (OR: 0.86, 95% CI: 0.73-1.02), vegetables (OR: 0.68, 95% CI: 0.56-0.84), and fruits and vegetables (OR: 0.61, 95% CI: 0.49-0.75); results were consistent across sociodemographic and lifestyles categories, as well as study characteristics. Exposure-response analyses showed an increasingly protective effect of portions/day of fruits (OR: 0.64, 95% CI: 0.57-0.73 for six portions), noncitrus fruits (OR: 0.71, 95% CI: 0.61-0.83 for six portions) and vegetables (OR: 0.51, 95% CI: 0.43-0.60 for 10 portions). A protective effect of all fruits, noncitrus fruits and vegetables was confirmed, supporting further dietary recommendations to decrease the burden of gastric cancer.
KW - fruits
KW - gastric cancer
KW - nutrition
KW - pooled analyses
KW - vegetables
UR - https://www.scopus.com/pages/publications/85087178829
U2 - 10.1002/ijc.33134
DO - 10.1002/ijc.33134
M3 - Article
C2 - 32525569
AN - SCOPUS:85087178829
SN - 0020-7136
VL - 147
SP - 3090
EP - 3101
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 11
ER -