FOXQ1 controls the induced differentiation of melanocytic cells

Archis Bagati; Anna Bianchi-Smiraglia; Sudha Moparthy; Kateryna Kolesnikova; Emily E. Fink; Masha Kolesnikova; Matthew V. Roll; Peter Jowdy; David W. Wolff; Anthony Polechetti; Dong Hyun Yun; Brittany C. Lipchick; Leslie M. Paul; Brian Wrazen; Kalyana Moparthy; Shaila Mudambi; Galina E. Morozevich; Sofia G. Georgieva; Jianmin Wang; Gal Shafirstein; Song Liu; Eugene S. Kandel; Albert E. Berman; Neil F. Box; Gyorgy Paragh; Mikhail A. Nikiforov

doi:10.1038/s41418-018-0066-y

FOXQ1 controls the induced differentiation of melanocytic cells

Archis Bagati
, Anna Bianchi-Smiraglia
, Sudha Moparthy
, Kateryna Kolesnikova
, Emily E. Fink
, Masha Kolesnikova
, Matthew V. Roll
, Peter Jowdy
, David W. Wolff
, Anthony Polechetti
, Dong Hyun Yun
, Brittany C. Lipchick
, Leslie M. Paul
, Brian Wrazen
, Kalyana Moparthy
, Shaila Mudambi
, Galina E. Morozevich
, Sofia G. Georgieva
, Jianmin Wang
, Gal Shafirstein

Song Liu, Eugene S. Kandel, Albert E. Berman, Neil F. Box, Gyorgy Paragh, Mikhail A. Nikiforov

Department of Biostatistics

Roswell Park Cancer Institute
Dana-Farber Cancer Institute
Orekhovich Institute of Biomedical Chemistry
Institute of Gene Biology, Russian Academy of Sciences
University of Colorado Anschutz Medical Campus

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Oncogenic transcription factor FOXQ1 has been implicated in promotion of multiple transformed phenotypes in carcinoma cells. Recently, we have characterized FOXQ1 as a melanoma tumor suppressor that acts via repression of N-cadherin gene, and invasion and metastasis. Here we report that FOXQ1 induces differentiation in normal and transformed melanocytic cells at least partially via direct transcriptional activation of MITF gene, melanocytic lineage-specific regulator of differentiation. Importantly, we demonstrate that pigmentation induced in cultured melanocytic cells and in mice by activation of cAMP/CREB1 pathway depends in large part on FOXQ1. Moreover, our data reveal that FOXQ1 acts as a critical mediator of BRAF^V600E-dependent regulation of MITF levels, thus providing a novel link between two major signal transduction pathways controlling MITF and differentiation in melanocytic cells.

Original language	English
Pages (from-to)	1040-1049
Number of pages	10
Journal	Cell Death and Differentiation
Volume	25
Issue number	6
DOIs	https://doi.org/10.1038/s41418-018-0066-y
State	Published - Jun 1 2018

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Bagati, A., Bianchi-Smiraglia, A., Moparthy, S., Kolesnikova, K., Fink, E. E., Kolesnikova, M., Roll, M. V., Jowdy, P., Wolff, D. W., Polechetti, A., Yun, D. H., Lipchick, B. C., Paul, L. M., Wrazen, B., Moparthy, K., Mudambi, S., Morozevich, G. E., Georgieva, S. G., Wang, J., ... Nikiforov, M. A. (2018). FOXQ1 controls the induced differentiation of melanocytic cells. Cell Death and Differentiation, 25(6), 1040-1049. https://doi.org/10.1038/s41418-018-0066-y

@article{485006b0b5184b2284ca0abb7b49795a,

title = "FOXQ1 controls the induced differentiation of melanocytic cells",

abstract = "Oncogenic transcription factor FOXQ1 has been implicated in promotion of multiple transformed phenotypes in carcinoma cells. Recently, we have characterized FOXQ1 as a melanoma tumor suppressor that acts via repression of N-cadherin gene, and invasion and metastasis. Here we report that FOXQ1 induces differentiation in normal and transformed melanocytic cells at least partially via direct transcriptional activation of MITF gene, melanocytic lineage-specific regulator of differentiation. Importantly, we demonstrate that pigmentation induced in cultured melanocytic cells and in mice by activation of cAMP/CREB1 pathway depends in large part on FOXQ1. Moreover, our data reveal that FOXQ1 acts as a critical mediator of BRAFV600E-dependent regulation of MITF levels, thus providing a novel link between two major signal transduction pathways controlling MITF and differentiation in melanocytic cells.",

author = "Archis Bagati and Anna Bianchi-Smiraglia and Sudha Moparthy and Kateryna Kolesnikova and Fink, \{Emily E.\} and Masha Kolesnikova and Roll, \{Matthew V.\} and Peter Jowdy and Wolff, \{David W.\} and Anthony Polechetti and Yun, \{Dong Hyun\} and Lipchick, \{Brittany C.\} and Paul, \{Leslie M.\} and Brian Wrazen and Kalyana Moparthy and Shaila Mudambi and Morozevich, \{Galina E.\} and Georgieva, \{Sofia G.\} and Jianmin Wang and Gal Shafirstein and Song Liu and Kandel, \{Eugene S.\} and Berman, \{Albert E.\} and Box, \{Neil F.\} and Gyorgy Paragh and Nikiforov, \{Mikhail A.\}",

note = "Publisher Copyright: {\textcopyright} 2018 ADMC Associazione Differenziamento e Morte Cellulare.",

year = "2018",

month = jun,

day = "1",

doi = "10.1038/s41418-018-0066-y",

language = "English",

volume = "25",

pages = "1040--1049",

journal = "Cell Death and Differentiation",

issn = "1350-9047",

publisher = "Springer Nature",

number = "6",

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Bagati, A, Bianchi-Smiraglia, A, Moparthy, S, Kolesnikova, K, Fink, EE, Kolesnikova, M, Roll, MV, Jowdy, P, Wolff, DW, Polechetti, A, Yun, DH, Lipchick, BC, Paul, LM, Wrazen, B, Moparthy, K, Mudambi, S, Morozevich, GE, Georgieva, SG, Wang, J, Shafirstein, G, Liu, S, Kandel, ES, Berman, AE, Box, NF, Paragh, G & Nikiforov, MA 2018, 'FOXQ1 controls the induced differentiation of melanocytic cells', Cell Death and Differentiation, vol. 25, no. 6, pp. 1040-1049. https://doi.org/10.1038/s41418-018-0066-y

TY - JOUR

T1 - FOXQ1 controls the induced differentiation of melanocytic cells

AU - Bagati, Archis

AU - Bianchi-Smiraglia, Anna

AU - Moparthy, Sudha

AU - Kolesnikova, Kateryna

AU - Fink, Emily E.

AU - Kolesnikova, Masha

AU - Roll, Matthew V.

AU - Jowdy, Peter

AU - Wolff, David W.

AU - Polechetti, Anthony

AU - Yun, Dong Hyun

AU - Lipchick, Brittany C.

AU - Paul, Leslie M.

AU - Wrazen, Brian

AU - Moparthy, Kalyana

AU - Mudambi, Shaila

AU - Morozevich, Galina E.

AU - Georgieva, Sofia G.

AU - Wang, Jianmin

AU - Shafirstein, Gal

AU - Liu, Song

AU - Kandel, Eugene S.

AU - Berman, Albert E.

AU - Box, Neil F.

AU - Paragh, Gyorgy

AU - Nikiforov, Mikhail A.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Oncogenic transcription factor FOXQ1 has been implicated in promotion of multiple transformed phenotypes in carcinoma cells. Recently, we have characterized FOXQ1 as a melanoma tumor suppressor that acts via repression of N-cadherin gene, and invasion and metastasis. Here we report that FOXQ1 induces differentiation in normal and transformed melanocytic cells at least partially via direct transcriptional activation of MITF gene, melanocytic lineage-specific regulator of differentiation. Importantly, we demonstrate that pigmentation induced in cultured melanocytic cells and in mice by activation of cAMP/CREB1 pathway depends in large part on FOXQ1. Moreover, our data reveal that FOXQ1 acts as a critical mediator of BRAFV600E-dependent regulation of MITF levels, thus providing a novel link between two major signal transduction pathways controlling MITF and differentiation in melanocytic cells.

AB - Oncogenic transcription factor FOXQ1 has been implicated in promotion of multiple transformed phenotypes in carcinoma cells. Recently, we have characterized FOXQ1 as a melanoma tumor suppressor that acts via repression of N-cadherin gene, and invasion and metastasis. Here we report that FOXQ1 induces differentiation in normal and transformed melanocytic cells at least partially via direct transcriptional activation of MITF gene, melanocytic lineage-specific regulator of differentiation. Importantly, we demonstrate that pigmentation induced in cultured melanocytic cells and in mice by activation of cAMP/CREB1 pathway depends in large part on FOXQ1. Moreover, our data reveal that FOXQ1 acts as a critical mediator of BRAFV600E-dependent regulation of MITF levels, thus providing a novel link between two major signal transduction pathways controlling MITF and differentiation in melanocytic cells.

UR - https://www.scopus.com/pages/publications/85042214028

U2 - 10.1038/s41418-018-0066-y

DO - 10.1038/s41418-018-0066-y

M3 - Article

C2 - 29463842

AN - SCOPUS:85042214028

SN - 1350-9047

VL - 25

SP - 1040

EP - 1049

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

IS - 6

ER -

FOXQ1 controls the induced differentiation of melanocytic cells

Abstract

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